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CAS 15174-69-3
4-hydroxy-3-methylbenzaldehyde
登记编号：TELM-013
应用背景（按来源药适应症）
高血压替米沙坦/苯磺酸氨氯地平/氢氯噻嗪高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦高血压苯磺酸氨氯地平/替米沙坦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 替米沙坦/苯磺酸氨氯地平/氢氯噻嗪Telmisartan/Amlodipine Besylate/Hydrochlorothiazide | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C · 观察 / 贸易 | - |
| 苯磺酸氨氯地平/替米沙坦Amlodipine Besylate/Telmisartan | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
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