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CAS 152628-01-8
methyl 4-butyramido-3-methyl-5-nitrobenzoate
登记编号：TELM-004
应用背景（按来源药适应症）
高血压替米沙坦/苯磺酸氨氯地平/氢氯噻嗪高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦高血压苯磺酸氨氯地平/替米沙坦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 替米沙坦/苯磺酸氨氯地平/氢氯噻嗪Telmisartan/Amlodipine Besylate/Hydrochlorothiazide | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C · 观察 / 贸易 | - |
| 苯磺酸氨氯地平/替米沙坦Amlodipine Besylate/Telmisartan | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
methyl 4-amino-3-methylbenzoate→butyryl chloride→methyl 4-butyramido-3-methylbenzoate→methyl 4-butyramido-3-methyl-5-nitrobenzoate→methyl 3-amino-4-butyramido-5-methylbenzoate→methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate→4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid→TELM-008→1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→tert-butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→tert-butyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
methyl 4-amino-3-methylbenzoate→butyryl chloride→methyl 4-butyramido-3-methylbenzoate→methyl 4-butyramido-3-methyl-5-nitrobenzoate→methyl 3-amino-4-butyramido-5-methylbenzoate→methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate→4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid→TELM-008→1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→tert-butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→tert-butyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
methyl 4-amino-3-methylbenzoate→butyryl chloride→methyl 4-butyramido-3-methylbenzoate→methyl 4-butyramido-3-methyl-5-nitrobenzoate→methyl 3-amino-4-butyramido-5-methylbenzoate→methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate→4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid→TELM-008→1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→tert-butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→tert-butyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
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