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CAS 153145-20-1
(1S,5S,6R,9S,10S,12R,15S)-9-(but-3-en-1-yl)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-ene-3,7-dione
登记编号：(XVII)101438-11-a,(XVII)101438-11-b
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(2R,4R,5S)-4,10,11,11-tetramethyltricyclo[5.3.1.0(1,5)]undec-9-ene-2,5-diol→(2R,4R,5S)-4,10,11,11-tetramethyl-2-[(triethylsilyl)oxy]tricyclo[5.3.1.0(1,5)]undec-9-en-5-ol→(1R,4R,6R,9S)-9-[(tert-butyldimethylsilyl)oxy]-4,8,11,11-tetramethyl-6-[(triethylsilyl)oxy]bicyclo[5.3.1]undec-7-en-3-one→4-Pentenal→(1S,2R,3S,4R,6R,9S)-9-[(tert-butyldimethylsilyl)oxy]-4-[(1S)-1-hydroxypent-4-en-1-yl]-4,8,11,11-tetramethyl-6-[(triethylsilyl)oxy]bicyclo[5.3.1]undec-7-ene-2,3-diol→(1R,4R,6R,9S)-9-[(tert-butyldimethylsilyl)oxy]-4-[(1S)-1-hydroxypent-4-en-1-yl]-4,8,11,11-tetramethyl-6-[(triethylsilyl)oxy]bicyclo[5.3.1]undec-7-en-3-one→(1S)-1-[(1R,4R,6R,9S)-9-[(tert-butyldimethylsilyl)oxy]-4,8,11,11-tetramethyl-3-oxo-6-[(triethylsilyl)oxy]bicyclo[5.3.1]undec-7-en-4-yl]pent-4-en-1-yl propanoate→7,7-dimethyl-1-[(oxaziridine-2-sulfonyl)methyl]bicyclo[2.2.1]heptan-2-one→(1S)-1-[(1S,2R,4R,6R,9S)-9-[(tert-butyldimethylsilyl)oxy]-2-hydroxy-4,8,11,11-tetramethyl-3-oxo-6-[(triethylsilyl)oxy]bicyclo[5.3.1]undec-7-en-4-yl]pent-4-en-1-yl propanoate→(1S,2R,3S,7S,8R,10R,13S)-7-(but-3-en-1-yl)-13-[(tert-butyldimethylsilyl)oxy]-2-hydroxy-8,12,15,15-tetramethyl-10-[(triethylsilyl)oxy]-4,6-dioxatricyclo[9.3.1.0(3,8)]pentadec-11-en-5-one→(1S,3S,7S,8R,10R,13S)-7-(but-3-en-1-yl)-13-[(tert-butyldimethylsilyl)oxy]-8,12,15,15-tetramethyl-10-[(triethylsilyl)oxy]-4,6-dioxatricyclo[9.3.1.0(3,8)]pentadec-11-ene-2,5-dione→(1S,3S,6S,7R,9R,12S)-6-(but-3-en-1-yl)-12-[(tert-butyldimethylsilyl)oxy]-3-hydroxy-7,11,14,14-tetramethyl-9-[(triethylsilyl)oxy]-5-oxatricyclo[8.3.1.0(3,7)]tetradec-10-ene-2,4-dione→(1S,6S,7S,9R,12S)-6-(but-3-en-1-yl)-12-[(tert-butyldimethylsilyl)oxy]-2-hydroxy-7,11,14,14-tetramethyl-9-[(triethylsilyl)oxy]-5-oxatricyclo[8.3.1.0(3,7)]tetradeca-2,10-dien-4-one→(1S,3R,6S,7S,9R,12S)-6-(but-3-en-1-yl)-12-[(tert-butyldimethylsilyl)oxy]-7,11,14,14-tetramethyl-9-[(triethylsilyl)oxy]-5-oxatricyclo[8.3.1.0(3,7)]tetradec-10-ene-2,4-dione→(1S,3S,6S,7S,9R,12S)-6-(but-3-en-1-yl)-12-[(tert-butyldimethylsilyl)oxy]-7,11,14,14-tetramethyl-9-[(triethylsilyl)oxy]-5-oxatricyclo[8.3.1.0(3,7)]tetradec-10-ene-2,4-dione→(1S,3R,6S,7S,9R,12S)-6-(but-3-en-1-yl)-12-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-7,11,14,14-tetramethyl-9-[(triethylsilyl)oxy]-5-oxatricyclo[8.3.1.0(3,7)]tetradec-10-ene-2,4-dione→(1S,3S,6S,7S,9R,12S)-6-(but-3-en-1-yl)-12-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-7,11,14,14-tetramethyl-9-[(triethylsilyl)oxy]-5-oxatricyclo[8.3.1.0(3,7)]tetradec-10-ene-2,4-dione→(1S,2S,3R,6S,7S,9R,12S)-6-(but-3-en-1-yl)-12-[(tert-butyldimethylsilyl)oxy]-1,2-dihydroxy-7,11,14,14-tetramethyl-9-[(triethylsilyl)oxy]-5-oxatricyclo[8.3.1.0(3,7)]tetradec-10-en-4-one→(1S,5S,6R,9S,10S,12R,15S)-9-(but-3-en-1-yl)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-ene-3,7-dione
methyl (1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-7,10-dihydroxy-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-diene-8-carboxylate→(1S,5S,6R,9S,10S,12R,15S)-9-(but-3-en-1-yl)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-ene-3,7-dione→methyl 3-[(1S,5S,6R,9S,10S,12R,15S)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-3,7-dioxo-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-en-9-yl]propanoate→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-10-(prop-1-en-2-yloxy)-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-hydroxy-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl 4-methylbenzene-1-sulfonate→(1S,5S,6S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-7-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-3-one→(1S,5S,6R,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-8-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(3aS,5S,8S,9aR,10S,12S,13aS,13bS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxy-6,9a,14,14-tetramethyl-13-methylidene-8-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl methanesulfonate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-3-one→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-13,17,20,20-tetramethyl-3-oxo-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-15-hydroxy-13,17,20,20-tetramethyl-3-oxo-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→2-Methoxy-1-propene
本站可供应的对应中间体
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