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CAS 155619-58-2
2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]acetaldehyde
登记编号：(XI)101438-15-a
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
6,6,8-Trimethyl-1,4-dioxaspiro[4.5]decan-7-one→6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl trifluoromethanesulfonate→7-ethenyl-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-ene→tert-butyl({[(7S)-9-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-8,10,10-trimethyl-1,4-dioxaspiro[4.5]dec-8-en-7-yl]oxy})dimethylsilane→2-{6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl}ethan-1-ol→tert-butyldimethyl(2-{6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl}ethoxy)silane→(3aS)-1,3,3-trimethyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole→(7S)-9-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-8,10,10-trimethyl-1,4-dioxaspiro[4.5]dec-8-en-7-ol→2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]ethan-1-ol→2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]acetaldehyde→tert-butyl({[(2E)-3-iodobut-2-en-1-yl]oxy})dimethylsilane→(3E)-4-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-3-methylbut-3-en-2-ol→(3E)-5-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-3-methylpent-3-en-2-one→1-[(1S,2R,3S,6S)-6-(benzyloxy)-2-(hydroxymethyl)-1-methyl-4-oxo-3-[(phenylsulfanyl)methyl]cyclohexyl]-2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]ethane-1,2-dione→(3E)-5-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-1-hydroxy-3-methylpent-3-en-2-one→(3E)-5-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-3-methylpent-3-ene-1,2-dione→[(2Z,3E)-4-(benzyloxy)-2-[2-(phenylsulfanyl)ethylidene]but-3-en-1-yl]trimethylsilane→1-[(1S,2R,3S,6S)-6-(benzyloxy)-2-{[(tert-butyldimethylsilyl)oxy]methyl}-1-methyl-4-oxo-3-[(phenylsulfanyl)methyl]cyclohexyl]-2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]ethane-1,2-dione→(1R,2S,3S,6S)-3-(benzyloxy)-2-{2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-2-oxoacetyl}-2-methyl-5-oxo-6-[(phenylsulfanyl)methyl]cyclohexane-1-carbaldehyde→(1R,2S,3S,6S)-3-(benzyloxy)-2-{2-[(3S)-3-hydroxy-2,6,6-trimethyl-5-oxocyclohex-1-en-1-yl]-2-oxoacetyl}-2-methyl-5-oxo-6-[(phenylsulfanyl)methyl]cyclohexane-1-carbaldehyde
本站可供应的对应中间体
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