← 返回专利悬崖列表
CAS 155619-70-8
(1S,3R,4S,7S,8S,10R,13S)-7-(benzyloxy)-13-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-8,12,15,15-tetramethyl-2,5,9-trioxo-4-[(phenylsulfanyl)methyl]tricyclo[9.3.1.0(3,8)]pentadec-11-en-10-yl acetate
登记编号：(XXIV)101438-15-b
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1R,2S,3S,6S)-3-(benzyloxy)-2-{2-[(3S)-3-hydroxy-2,6,6-trimethyl-5-oxocyclohex-1-en-1-yl]-2-oxoacetyl}-2-methyl-5-oxo-6-[(phenylsulfanyl)methyl]cyclohexane-1-carbaldehyde→(1S,3R,4S,7S,8S,10R,13S)-7-(benzyloxy)-1,2,5,10,13-pentahydroxy-8,12,15,15-tetramethyl-4-[(phenylsulfanyl)methyl]tricyclo[9.3.1.0(3,8)]pentadec-11-en-9-one→(1S,3R,4S,7S,8S,10R,13S)-7-(benzyloxy)-13-[(tert-butyldimethylsilyl)oxy]-1,2,5-trihydroxy-8,12,15,15-tetramethyl-9-oxo-4-[(phenylsulfanyl)methyl]tricyclo[9.3.1.0(3,8)]pentadec-11-en-10-yl acetate→(1S,3R,4S,7S,8S,10R,13S)-7-(benzyloxy)-13-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-8,12,15,15-tetramethyl-2,5,9-trioxo-4-[(phenylsulfanyl)methyl]tricyclo[9.3.1.0(3,8)]pentadec-11-en-10-yl acetate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-bis(benzyloxy)-15-hydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(1S,2S,3R,4S,7S,8S,10R,13S)-7-(benzyloxy)-13-[(tert-butyldimethylsilyl)oxy]-1,2-dihydroxy-8,12,15,15-tetramethyl-5,9-dioxo-4-[(phenylsulfanyl)methyl]tricyclo[9.3.1.0(3,8)]pentadec-11-en-10-yl acetate→(1S,2S,3R,4S,7S,8S,10R,13S)-10-(acetyloxy)-1,7-bis(benzyloxy)-13-[(tert-butyldimethylsilyl)oxy]-8,12,15,15-tetramethyl-5,9-dioxo-4-[(phenylsulfanyl)methyl]tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3R,4S,5R,7S,8S,10R,13S)-10-(acetyloxy)-1,7-bis(benzyloxy)-13-[(tert-butyldimethylsilyl)oxy]-4,5-dihydroxy-4-(hydroxymethyl)-8,12,15,15-tetramethyl-9-oxotricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-12-(acetyloxy)-1,9-bis(benzyloxy)-15-[(tert-butyldimethylsilyl)oxy]-4-hydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-bis(benzyloxy)-15-{[(2R,3S)-2-(2-ethoxyethoxy)-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。