← 返回专利悬崖列表
CAS 1631050-05-9
((2R,3R,4R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)tetrahydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate
登记编号：CENSA-005
应用背景（按来源药适应症）
进行性核上性麻痹Censavudine额颞痴呆Censavudine肌萎缩性侧索硬化CensavudineAicardi综合征CensavudineHIV感染Censavudine
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Censavudine | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-methyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→[1,1'-biphenyl]-4-carbonyl chloride→((3aR,4R,6R,6aR)-2-methyl-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl [1,1'-biphenyl]-4-carboxylate→((2R,3R,4R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)tetrahydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate→((2R,3S,4S,5R)-3-iodo-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)tetrahydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate→((4R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)-4,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate→((2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(2-oxoethyl)-2,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate→((2R,5R)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate→1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。