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CAS 171866-29-8
((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate
登记编号：CLEVU-007
应用背景（按来源药适应症）
乙型肝炎克拉夫定新型冠状病毒感染克拉夫定
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 克拉夫定Clevudine | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(3S,4R,5S)-5-(hydroxymethyl)tetrahydrofuran-2,3,4-triol→(2S,3S,4S)-2-((benzoyloxy)methyl)-5-methoxytetrahydrofuran-3,4-diyl dibenzoate→(2R,3S,4S,5S)-2-acetoxy-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate→(2S,3S,4R,5S)-5-((benzoyloxy)methyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate→(2S,3S,4S,5S)-3-(((1H-imidazol-1-yl)sulfonyl)oxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,4-diyl dibenzoate→(2S,3R,4S,5S)-5-((benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate→5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine→((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate
((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate→(3R,4S,5S)-tetrahydro-2H-pyran-2,3,4,5-tetraol→(3R,4S,5S)-tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate→(2R,3R,4S,5S)-2-bromotetrahydro-2H-pyran-3,4,5-triyl triacetate→(3S,4R)-3,4-dihydro-2H-pyran-3,4-diyl diacetate→(3S,4S,5R)-5-fluoro-6-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate→(3R,4S,5S)-3-fluorotetrahydro-2H-pyran-2,4,5-triol→(2S,3S,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3-ol→((2S,3S,4R,5R)-3-(benzoyloxy)-4-fluoro-5-methoxytetrahydrofuran-2-yl)methyl benzoate→5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine
(2S,3S,4R,5S)-5-((benzoyloxy)methyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate→(2S,3S,4S,5S)-3-(((1H-imidazol-1-yl)sulfonyl)oxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,4-diyl dibenzoate→(2S,3R,4S,5S)-5-((benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate→5-methylpyrimidine-2,4(1H,3H)-dione
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