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CAS 1826-67-1
(Vinyl)magnesium bromidevinylmagnesium bromide
登记编号：(VIII)101438-67-a、(VII)101438-68-a、DARU-032
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylateHIV感染乙醇达芦那韦/利托那韦HIV感染乙醇达芦那韦/考比司他
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/考比司他Darunavir Ethanolate/Cobicistat | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
3-Methyl-2-butenal→2-Bromo-3-methylbut-2-enal→(Trimethylsilyl)methyl chloride→3-Bromo-4-methyl-1-(trimethylsilyl)pent-3-en-2-ol→1-[6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-en-1-yl]prop-2-en-1-ol→3-Bromo-4-methylpenta-1,3-diene→3-Methyl-2-cyclohexen-1-one→6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-ene-1-carbaldehyde→(Vinyl)magnesium bromide→2-Isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-ol→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-one→(12aS)-4-Chloro-9,12a,13,13-tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulen-5(1H)-one
(3S,4aR,6R,11S,12aS)-3-Bromo-9,12a,13,13-tetramethyl-11-[(triethylsilyl)oxy]-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(3S,4aR,6R,12aR)-3-Bromo-9,12a,13,13-tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,11S,12aS)-9,12a,13,13-Tetramethyl-11-[(triethylsilyl)oxy]-4a,6,7,11,12,12a-hexahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→1,1-Dibromo-2,2,3,3-tetramethylcyclopropane→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5(1H,4aH)-dione→(Vinyl)magnesium bromide→1,1,2,2-Tetramethylethylene→2-Hydroxy-2-methylbutanoic acid→2-Propen-1-one→3-(3-Isopropenyl-4-methyl-3-pentenyl)-2-cyclohexen-1-one→3-Bromo-2,4-dimethylpenta-1,3-diene→3-Ethenylcyclohex-2-en-1-one→3-Ethoxy-2-cyclohexen-1-one→Aluminum trimethanide→Methylmagnesium bromide→Bromoform→Trimethyl([(3S)-3-methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]oxy)silane→(2beta,4alpha,10beta,13alpha)-10-[(Triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-2,4,13-triol→(2S,3S)-2,3-Dimethyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one→(2S,3S)-3-Methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
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