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CAS 1980822-14-7
2-Hydroxyethane-1-sulfonic acid 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperidin-4-yl)pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
登记编号：Dalpiciclib Isethionate-014
应用背景（按来源药适应症）
乳腺癌羟乙磺酸达尔西利转移性乳腺癌羟乙磺酸达尔西利前列腺癌羟乙磺酸达尔西利三阴性乳腺癌羟乙磺酸达尔西利脑膜瘤羟乙磺酸达尔西利肝功能衰退羟乙磺酸达尔西利
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 羟乙磺酸达尔西利Dalpiciclib Isethionate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one→tert-Butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate→1-(Vinyloxy)butane→tert-Butyl 4-(6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl)piperidine-1-carboxylate→tert-Butyl 4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate→2-Hydroxyethane-1-sulfonic acid 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperidin-4-yl)pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one→2-Amino-6-bromo-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→2-Amino-6-(1-butoxyethenyl)-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→tert-Butyl 6-chloro-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate→5-Bromo-2-chloropyridine→tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate→tert-Butyl 6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate
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