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CAS 201226-28-0
(3aR,4R,5R,6aS)-4-(3-((tert-butyldimethylsilyl)oxy)-4,4-difluorooctyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
登记编号：LUBI-022
应用背景（按来源药适应症）
便秘芦比前列酮阿片类药物引起的便秘芦比前列酮慢性特发性便秘芦比前列酮药物相关的副作用和不良反应芦比前列酮非酒精性脂肪性肝炎芦比前列酮腹膜癌芦比前列酮
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 芦比前列酮Lubiprostone | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate→(Z)-7-((1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoic acid→(3aR,4S,5R,6aS)-2-oxo-4-(((trimethylsilyl)oxy)methyl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4R,5R,6aS)-4-((E)-4,4-difluoro-3-oxooct-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4R,5R,6aS)-4-(4,4-difluoro-3-oxooctyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4R,5R,6aS)-4-(4,4-difluoro-3-hydroxyoctyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4R,5R,6aS)-4-(3-((tert-butyldimethylsilyl)oxy)-4,4-difluorooctyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4R,5R,6aS)-4-(3-((tert-butyldimethylsilyl)oxy)-4,4-difluorooctyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4R,5R,6aS)-4-(3-((tert-butyldimethylsilyl)oxy)-4,4-difluorooctyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-ol→(6-methoxy-6-oxohexyl)triphenylphosphonium bromide→methyl (Z)-7-((1R,2R,3R,5S)-2-(3-((tert-butyldimethylsilyl)oxy)-4,4-difluorooctyl)-5-hydroxy-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate→methyl (Z)-7-((1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate
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