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CAS 259214-56-7
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride
登记编号：DANOP-001、SIME-005
应用背景（按来源药适应症）
丙型肝炎达诺瑞韦钠慢性丙型肝炎达诺瑞韦钠病毒感染达诺瑞韦钠丙型肝炎西美瑞韦钠慢性丙型肝炎西美瑞韦钠麻疹西美瑞韦钠结核分枝杆菌感染西美瑞韦钠
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride→1-(tert-butyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate→(2S,4R)-tert-butyl 2-(((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropyl)carbamoyl)-4-hydroxypyrrolidine-1-carboxylate→(S)-2-((tert-butoxycarbonyl)amino)non-8-enoic acid→(1R,2S)-ethyl 1-((2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate→(2R,6S,13aS,14aR,16aS,Z)-ethyl 6-((tert-butoxycarbonyl)amino)-2-hydroxy-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate→1-(8-methoxy-4-(o-tolylamino)quinolin-3-yl)butan-1-one→(2R,6S,13aS,14aR,16aS,Z)-ethyl 6-((tert-butoxycarbonyl)amino)-2-((4-fluoroisoindoline-2-carbonyl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate→(2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-2-((4-fluoroisoindoline-2-carbonyl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylic acid→cyclopropanesulfonamide
3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid→N-methylhex-5-en-1-amine→(1R,4R,5R)-N-(hex-5-en-1-yl)-N-methyl-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxamide→(1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentanecarboxylic acid→(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride→(1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate→2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol→(1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate→(2R,3aR,11aS,12aR,14aR,Z)-ethyl 2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,12a,13,14,14a-hexadecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a-carboxylate→cyclopropanesulfonamide
本站可供应的对应中间体
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