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CAS 29632-74-4
2-fluoro-4-iodoaniline
登记编号：OSIM-019、TRAT-001、COBI-013
应用背景（按来源药适应症）
非小细胞肺癌甲磺酸奥希替尼甲状腺瘤曲美替尼胶质瘤曲美替尼毛细胞白血病曲美替尼甲状腺未分化癌曲美替尼实体瘤曲美替尼非小细胞肺癌曲美替尼黑色素瘤可美替尼
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→2-fluoro-4-iodoaniline→hexane-2,5-dione→1-(2-fluoro-4-iodophenyl)-2,5-dimethyl-1H-pyrrole→1-(2-fluoro-4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole→2-fluoro-4-methoxyaniline→N-(2-fluoro-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-nitrophenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-guanidino-4-methoxyphenyl)acrylamide→(E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)prop-2-en-1-one→1-(1-methyl-1H-indol-3-yl)ethanone
2-fluoro-4-iodoaniline→cyclopropanamine→1-cyclopropyl-3-(2-fluoro-4-iodophenyl)urea→2-cyanoacetic acid→2-cyano-N-cyclopropyl-N-((2-fluoro-4-iodophenyl)carbamoyl)acetamide→6-amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyrimidine-2,4(1H,3H)-dione→(E)-N'-(1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione→2-methylmalonic acid→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate→N-(3-aminophenyl)acetamide→N-(3-((3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
azetidin-3-ol hydrochloride→benzyl 3-hydroxyazetidine-1-carboxylate→benzyl 3-oxoazetidine-1-carboxylate→tert-butyl piperidine-1-carboxylate→tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride→(S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-(((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)oxy)azetidin-3-yl)piperidine-1-carboxylate→(S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→(S)-tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl fluoride→(S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→2,3,4-trifluorobenzoic acid→2-fluoro-4-iodoaniline→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid→2,4,6-trifluoro-1,3,5-triazine
2,3,4-trifluorobenzoic acid→2-fluoro-4-iodoaniline→(3S,5R,8aS)-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridine-5-carbonitrile→tert-butyl 3-oxoazetidine-1-carboxylate→tert-butyl 3-((3S,5R,8aS)-5-cyano-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridin-5-yl)-3-hydroxyazetidine-1-carboxylate→tert-butyl 3-hydroxy-3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidine-1-carboxylate→3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidin-3-ol→(3-hydroxy-3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidin-1-yl)(2,3,4-trifluorophenyl)methanone→(S)-(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)(2,3,4-trifluorophenyl)methanone hydrochloride
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同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-Fluoro-4-iodoaniline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。