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CAS 4271-30-1
N-(4-Aminobenzoyl)-L-glutamic acid
登记编号：Folic Acid-015
应用背景（按来源药适应症）
原发性高血压马来酸依那普利/叶酸巨幼红细胞性贫血叶酸叶酸缺乏叶酸神经管缺损叶酸贫血叶酸热潮红叶酸高同型半胱氨酸血症叶酸
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 马来酸依那普利/叶酸Enalapril Maleate/Folic Acid | Tier C · 观察 / 贸易 | - |
| 叶酸Folic Acid | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
N-(4-Aminobenzoyl)-L-glutamic acid→N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester→2,3-Dibromopropanal→N-[4-(2,3-Dibromopropylideneamino)benzoyl]-L-glutamic acid diethyl diester→2,5,6-Triaminopyrimidin-4(5H)-one→N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester
2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→2,3-Dichloropropanal→2,3-Dibromopropanal
[1,3-13C]Propan-2-one→1,1,3-Trichloro[1,3-13C]propan-2-one→1,3-Dichloro[1,3-13C]propan-2-one→2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→N-[[4-([[2-Amino-4-oxo[7-13C]-4,4a-dihydropteridin-6-yl][13C]methyl]amino)phenyl]carbonyl]-L-glutamic acid
2-Propenal→2,3-Dibromopropanal→2-Bromo-1,1,3-triethoxypropane→1,3,3-Triethoxyprop-1-ene→1,2-Dibromo-1,3,3-triethoxypropane→2-Bromo-3,3-diethoxypropanal→2,5,6-Triaminopyrimidin-4(5H)-one hydrochloride→2-Amino-6-(diethoxymethyl)pteridin-4(1H)-one→N-[6-(Diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide→N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide→N-(4-Aminobenzoyl)-L-glutamic acid→N-([4-[[[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl](formyl)amino]phenyl]carbonyl)-L-glutamic acid→N-[[4-([[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)phenyl]carbonyl]-L-glutamic acid
4-Nitrobenzoyl chloride→(S)-(+)-Glutamic acid→(2S)-[(4-Nitrobenzoyl)amino]pentanedioic acid→Sodium 1-[[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl]-4-nitrobenzene→N-(4-Aminobenzoyl)-L-glutamic acid→2,5,6-Triaminopyrimidin-4(5H)-one→2,5,6-Triaminopyrimidin-4-one sulfate→1,1,3-Trichloroacetone
(Methoxycarbonyl)acetonitrile→Guanidine sulfate→2,4-Diamino-6-hydroxypyrimidine→2,4-Diamino-6-hydroxy-5-nitrosopyrimidine→2,5,6-Triaminopyrimidin-4-ol→Sulfuric acid 2,5,6-triaminopyrimidin-4(1H)-one→2,5,6-Triaminopyrimidin-4-ol dihydrobromide→2,5,6-Triaminopyrimidin-4-one dihydrochloride→3-Bromo-2-oxopropanal oxime→1-Chloro-3-(hydroxyimino)propan-2-one→2-Amino-6-(bromomethyl)-4-pteridinol→2-Amino-6-(chloromethyl)-4-pteridinol→N-(4-Aminobenzoyl)-L-glutamic acid
N-(4-Aminobenzoyl)-L-glutamic acid→N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester→2,3-Dibromopropanal→N-[4-(2,3-Dibromopropylideneamino)benzoyl]-L-glutamic acid diethyl diester→2,5,6-Triaminopyrimidin-4(5H)-one→N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester
2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→2,3-Dichloropropanal→2,3-Dibromopropanal
[1,3-13C]Propan-2-one→1,1,3-Trichloro[1,3-13C]propan-2-one→1,3-Dichloro[1,3-13C]propan-2-one→2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→N-[[4-([[2-Amino-4-oxo[7-13C]-4,4a-dihydropteridin-6-yl][13C]methyl]amino)phenyl]carbonyl]-L-glutamic acid
2-Propenal→2,3-Dibromopropanal→2-Bromo-1,1,3-triethoxypropane→1,3,3-Triethoxyprop-1-ene→1,2-Dibromo-1,3,3-triethoxypropane→2-Bromo-3,3-diethoxypropanal→2,5,6-Triaminopyrimidin-4(5H)-one hydrochloride→2-Amino-6-(diethoxymethyl)pteridin-4(1H)-one→N-[6-(Diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide→N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide→N-(4-Aminobenzoyl)-L-glutamic acid→N-([4-[[[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl](formyl)amino]phenyl]carbonyl)-L-glutamic acid→N-[[4-([[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)phenyl]carbonyl]-L-glutamic acid
4-Nitrobenzoyl chloride→(S)-(+)-Glutamic acid→(2S)-[(4-Nitrobenzoyl)amino]pentanedioic acid→Sodium 1-[[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl]-4-nitrobenzene→N-(4-Aminobenzoyl)-L-glutamic acid→2,5,6-Triaminopyrimidin-4(5H)-one→2,5,6-Triaminopyrimidin-4-one sulfate→1,1,3-Trichloroacetone
(Methoxycarbonyl)acetonitrile→Guanidine sulfate→2,4-Diamino-6-hydroxypyrimidine→2,4-Diamino-6-hydroxy-5-nitrosopyrimidine→2,5,6-Triaminopyrimidin-4-ol→Sulfuric acid 2,5,6-triaminopyrimidin-4(1H)-one→2,5,6-Triaminopyrimidin-4-ol dihydrobromide→2,5,6-Triaminopyrimidin-4-one dihydrochloride→3-Bromo-2-oxopropanal oxime→1-Chloro-3-(hydroxyimino)propan-2-one→2-Amino-6-(bromomethyl)-4-pteridinol→2-Amino-6-(chloromethyl)-4-pteridinol→N-(4-Aminobenzoyl)-L-glutamic acid
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