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CAS 49644-02-2
(5S,6S,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one
登记编号：ISTA-009
应用背景（按来源药适应症）
心源性休克Istaroxime心脏衰竭Istaroxime急性失代偿性心力衰竭Istaroxime
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Istaroxime | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-3,4,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(2H)-one→(3S,8R,9S,10R,13S,14S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one→(3S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol→(3S,5S,6S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diol→(3S,5S,6S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diyl diacetate→(3S,5S,6S,8R,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diyl diacetate→2-iodosylbenzoic acid→(5S,6S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthrene-6,17-diyl diacetate→(5S,6S,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one→2-(aminooxy)ethanamine→(5S,6S,8R,9S,10R,13S,14S,17S,E)-6,17-dihydroxy-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one O-(2-aminoethyl) oxime
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