← 返回专利悬崖列表
CAS 61079-72-9
2,3,4-trifluorobenzoic acid
登记编号：COBI-012、SELT-001、BINI-001
应用背景（按来源药适应症）
黑色素瘤可美替尼丛状神经纤维瘤硫酸氢司美替尼神经纤维瘤病I型硫酸氢司美替尼非小细胞肺癌贝美替尼黑色素瘤贝美替尼结直肠癌贝美替尼毛细胞白血病贝美替尼丛状神经纤维瘤贝美替尼神经纤维瘤病I型贝美替尼
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
azetidin-3-ol hydrochloride→benzyl 3-hydroxyazetidine-1-carboxylate→benzyl 3-oxoazetidine-1-carboxylate→tert-butyl piperidine-1-carboxylate→tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride→(S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-(((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)oxy)azetidin-3-yl)piperidine-1-carboxylate→(S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→(S)-tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl fluoride→(S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→2,3,4-trifluorobenzoic acid→2-fluoro-4-iodoaniline→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid→2,4,6-trifluoro-1,3,5-triazine
2,3,4-trifluorobenzoic acid→2-fluoro-4-iodoaniline→(3S,5R,8aS)-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridine-5-carbonitrile→tert-butyl 3-oxoazetidine-1-carboxylate→tert-butyl 3-((3S,5R,8aS)-5-cyano-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridin-5-yl)-3-hydroxyazetidine-1-carboxylate→tert-butyl 3-hydroxy-3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidine-1-carboxylate→3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidin-3-ol→(3-hydroxy-3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidin-1-yl)(2,3,4-trifluorophenyl)methanone→(S)-(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)(2,3,4-trifluorophenyl)methanone hydrochloride
2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→aniline→SELT-006→SELT-007→SELT-008→SELT-009→SELT-010→SELT-011→methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate→SELT-013
2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→2-fluoroaniline→methyl 4-amino-3-fluoro-2-((2-fluorophenyl)amino)-5-nitrobenzoate→methyl 4-fluoro-5-((2-fluorophenyl)amino)-1H-benzo[d]imidazole-6-carboxylate→methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1H-benzo[d]imidazole-6-carboxylate→methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid→methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate→5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→methyl 2,4-diamino-3-fluoro-5-nitrobenzoate→methyl 2,4,5-triamino-3-fluorobenzoate→diethoxymethane→methyl 5-amino-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→4-bromo-2-fluoro-1-iodobenzene→potassium 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazol-6-yl)(1H-imidazol-1-yl)methanone→O-(2-(tert-butoxy)ethyl)hydroxylamine→5-((4-bromo-2-fluorophenyl)amino)-N-(2-(tert-butoxy)ethoxy)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide hydrate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。