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CAS 65025-94-7
(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one
登记编号：TAFL-022、LUBI-041
应用背景（按来源药适应症）
高眼压他氟前列素开角型青光眼他氟前列素青光眼他氟前列素便秘芦比前列酮阿片类药物引起的便秘芦比前列酮慢性特发性便秘芦比前列酮药物相关的副作用和不良反应芦比前列酮非酒精性脂肪性肝炎芦比前列酮腹膜癌芦比前列酮
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(4-carboxybutyl)triphenylphosphonium bromide→tert-butyl 5-formylpyrazine-2-carboxylate→(3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-ol→(Z)-7-((1R,2S,3R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxy-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoic acid→isopropyl (Z)-7-((1R,2S,3R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxy-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2S,3R,5S)-5-acetoxy-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2S,3R,5S)-5-acetoxy-2-(hydroxymethyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-2-formyl-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate→dimethyl (2-oxo-3-phenoxypropyl)phosphonate→isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-2-((E)-3-oxo-4-phenoxybut-1-en-1-yl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-3-hydroxy-2-((E)-3-oxo-4-phenoxybut-1-en-1-yl)cyclopentyl)hept-5-enoate→(1R,3S,4R,5R)-4-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)-5-((E)-3-oxo-4-phenoxybut-1-en-1-yl)cyclopentane-1,3-diyl diacetate→(1S,3R,4R,5R)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl diacetate
dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate→(5-carboxypentyl)triphenylphosphonium bromide→(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-((4-methoxybenzyl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-((4-methoxybenzyl)oxy)hexahydro-2H-cyclopenta[b]furan-2-ol→(Z)-7-((1R,2S,3R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxy-3-((4-methoxybenzyl)oxy)cyclopentyl)hept-5-enoic acid→benzyl (Z)-7-((1R,2S,3R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxy-3-((4-methoxybenzyl)oxy)cyclopentyl)hept-5-enoate→benzyl (Z)-7-((1R,2S,3R,5S)-5-hydroxy-2-(hydroxymethyl)-3-((4-methoxybenzyl)oxy)cyclopentyl)hept-5-enoate→benzyl (Z)-7-((1R,2R,3R,5S)-2-formyl-5-hydroxy-3-((4-methoxybenzyl)oxy)cyclopentyl)hept-5-enoate→benzyl (Z)-7-((1R,2R,3R)-2-((E)-4,4-difluoro-3-oxooct-1-en-1-yl)-3-((4-methoxybenzyl)oxy)-5-oxocyclopentyl)hept-5-enoate
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