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CAS 6526-08-5
2-amino-5-(trifluoromethyl)benzonitrile
登记编号：ANAC-002
应用背景（按来源药适应症）
高胆固醇血症Anacetrapib心脏和血管疾病Anacetrapib血脂障碍Anacetrapib动脉粥样硬化AnacetrapibII型高脂蛋白血症Anacetrapib纯合子家族性高胆固醇血症Anacetrapib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Anacetrapib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-iodo-4-(trifluoromethyl)aniline→2-amino-5-(trifluoromethyl)benzonitrile→2-iodo-5-(trifluoromethyl)benzonitrile →2-iodo-5-(trifluoromethyl)benzoic acid→[2-iodo-5-(trifluoromethyl)phenyl]methanol →2-(bromomethyl)-1-iodo-4-(trifluoromethyl)benzene→(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-(2-iodo-5-(trifluoromethyl)benzyl)-4-methyloxazolidin-2-one→(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→3,5-bis(trifluoromethyl)benzaldehyde→nitroethane→1-(3,5-bis(trifluoromethyl)phenyl)-2-nitropropan-1-ol→2-amino-1-(3,5-bis(trifluoromethyl)phenyl)propan-1-ol→5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→1-(2-fluoro-4-methoxyphenyl)ethan-1-one→2-(2-fluoro-4-methoxyphenyl)propan-2-ol→2-fluoro-1-isopropyl-4-methoxybenzene→1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene
2-iodo-4-(trifluoromethyl)aniline→2-amino-5-(trifluoromethyl)benzonitrile→2-iodo-5-(trifluoromethyl)benzonitrile →2-iodo-5-(trifluoromethyl)benzoic acid→[2-iodo-5-(trifluoromethyl)phenyl]methanol →(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid→N,O-dimethylhydroxylamine→1-bromo-3,5-bis(trifluoromethyl)benzene→1-bromo-3,5-bis(trifluoromethyl)benzene→benzyl (S)-(1-(3,5-bis(trifluoromethyl)phenyl)-1-oxopropan-2-yl)carbamate→benzyl ((1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-yl)carbamate
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本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。