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CAS 749863-31-8
methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate
登记编号：CAROM-008、CAROM-021
应用背景（按来源药适应症）
溃疡性结肠炎Carotegrast methyl
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Carotegrast methyl | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(S)-2-amino-3-(4-nitrophenyl)propanoic acid→2,6-dichlorobenzoyl chloride→(S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoic acid→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoate→methyl (S)-3-(4-aminophenyl)-2-(2,6-dichlorobenzamido)propanoate→methyl 2-amino-5-(dimethylamino)benzoate dihydrochloride→methyl (S)-2-(3-(4-(2-(2,6-dichlorobenzamido)-3-methoxy-3-oxopropyl)phenyl)ureido)-5-(dimethylamino)benzoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate→5-chloro-2-nitrobenzoic acid→5-(dimethylamino)-2-nitrobenzoic acid→methyl 5-(dimethylamino)-2-nitrobenzoate
2,6-dichlorobenzoyl chloride→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid→methyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoate→methyl (S)-2-amino-3-(4-nitrophenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoate→methyl (S)-3-(4-aminophenyl)-2-(2,6-dichlorobenzamido)propanoate→5-fluoro-2-nitrobenzoic acid→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-fluoro-2-nitrobenzamido)phenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-(dimethylamino)-2-nitrobenzamido)phenyl)propanoate→methyl (S)-3-(4-(2-amino-5-(dimethylamino)benzamido)phenyl)-2-(2,6-dichlorobenzamido)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate
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