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CAS 762-04-9
Diethyl phosphonate
登记编号：Tenofovir disoproxil phosphate-005
应用背景（按来源药适应症）
HIV感染拉米夫定/富马酸替诺福韦二吡呋酯慢性乙型肝炎拉米夫定/富马酸替诺福韦二吡呋酯HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯HIV感染恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 拉米夫定/富马酸替诺福韦二吡呋酯Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Chloroacetyl chloride→1-Chloro-2(R)-propanol→Diethyl (tosyloxy)methylphosphonate→Diethyl (chloromethyl)phosphonate→Diethyl phosphonate→Diethyl phosphonomethanol→Diethyl (2-chloro-1(R)-methylethoxy)methylphosphonate→6-Aminopurine→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-9-(2-Phosphonomethoxypropyl)adenine→Chloromethyl isopropyl carbonate→Bis[[(isopropoxycarbonyl)oxy]methyl] ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→2(R)-Methyloxirane→(R)-(+)-9-(2-Hydroxypropyl)adenine→(R)-Propylene carbonate→(S)-Glycidol→(R)-1,2-Propanediol
Diethyl phosphonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-(+)-9-(2-Hydroxypropyl)adenine→(2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol→6-Chloro-9H-purine→1-Bromopropan-2-one→1-(6-Chloro-9H-purin-9-yl)acetone→Diethoxyphosphoryl)methyl triflate→Diethyl [2-(6-chloropurin-9-yl)-1(R)-methylethyloxy]methylphosphonate→1-(6-Amino-9H-purin-9-yl)acetone
Chloroacetyl chloride→1-Chloro-2(R)-propanol→Diethyl (tosyloxy)methylphosphonate→Diethyl (chloromethyl)phosphonate→Diethyl phosphonate→Diethyl phosphonomethanol→Diethyl (2-chloro-1(R)-methylethoxy)methylphosphonate→6-Aminopurine→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-9-(2-Phosphonomethoxypropyl)adenine→Chloromethyl isopropyl carbonate→Bis[[(isopropoxycarbonyl)oxy]methyl] ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→2(R)-Methyloxirane→(R)-(+)-9-(2-Hydroxypropyl)adenine→(R)-Propylene carbonate→(S)-Glycidol→(R)-1,2-Propanediol
Diethyl phosphonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-(+)-9-(2-Hydroxypropyl)adenine→(2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol→6-Chloro-9H-purine→1-Bromopropan-2-one→1-(6-Chloro-9H-purin-9-yl)acetone→Diethoxyphosphoryl)methyl triflate→Diethyl [2-(6-chloropurin-9-yl)-1(R)-methylethyloxy]methylphosphonate→1-(6-Amino-9H-purin-9-yl)acetone
Chloroacetyl chloride→1-Chloro-2(R)-propanol→Diethyl (tosyloxy)methylphosphonate→Diethyl (chloromethyl)phosphonate→Diethyl phosphonate→Diethyl phosphonomethanol→Diethyl (2-chloro-1(R)-methylethoxy)methylphosphonate→6-Aminopurine→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-9-(2-Phosphonomethoxypropyl)adenine→Chloromethyl isopropyl carbonate→Bis[[(isopropoxycarbonyl)oxy]methyl] ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→2(R)-Methyloxirane→(R)-(+)-9-(2-Hydroxypropyl)adenine→(R)-Propylene carbonate→(S)-Glycidol→(R)-1,2-Propanediol
Diethyl phosphonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→(R)-(+)-9-(2-Hydroxypropyl)adenine→(2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol→6-Chloro-9H-purine→1-Bromopropan-2-one→1-(6-Chloro-9H-purin-9-yl)acetone→Diethoxyphosphoryl)methyl triflate→Diethyl [2-(6-chloropurin-9-yl)-1(R)-methylethyloxy]methylphosphonate→1-(6-Amino-9H-purin-9-yl)acetone
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