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CAS 7693-46-1
4-nitrophenyl carbonochloridate
登记编号：EFAV-020、RITO-019、SOLIF-013、AZIL-039
应用背景（按来源药适应症）
HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯慢性丙型肝炎帕利普韦/奥比他韦/利托那韦丙型肝炎帕利普韦/奥比他韦/利托那韦失代偿性肝硬化帕利普韦/奥比他韦/利托那韦肾功能不全帕利普韦/奥比他韦/利托那韦纤维化帕利普韦/奥比他韦/利托那韦终末期肾脏病帕利普韦/奥比他韦/利托那韦HIV感染乙醇达芦那韦/利托那韦下尿路症状琥珀酸索利那新/盐酸坦洛新前列腺增生琥珀酸索利那新/盐酸坦洛新膀胱过度活动症琥珀酸索利那新/盐酸坦洛新药物相关的副作用和不良反应琥珀酸索利那新/盐酸坦洛新膀胱颈梗阻琥珀酸索利那新/盐酸坦洛新高血压阿齐沙坦酯钾盐/氯噻酮原发性高血压阿齐沙坦酯钾盐/氯噻酮
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 帕利普韦/奥比他韦/利托那韦Paritaprevir/Ombitasvir/Ritonavir | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C · 观察 / 贸易 | - |
| 琥珀酸索利那新/盐酸坦洛新Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 阿齐沙坦酯钾盐/氯噻酮Azilsartan Medoxomil Potassium/Chlorthalidone | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
ethynylcyclopropane→2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→5-chloro-2-nitrobenzaldehyde→1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-ol→1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one→(1R,2R,4R,5S)-1-(3,5-bis(trifluoromethyl)benzyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide→(S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→4-nitrophenyl carbonochloridate
(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→(S)-benzyl (1-oxo-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→1-bromo-2-methyl-1-oxopropan-2-yl acetate→(5S,6R,7R,8S)-5,8-dibenzyl-7-bromo-3,10-dioxo-1,12-diphenyl-2,11-dioxa-4,9-diazadodecan-6-yl acetate→dibenzyl ((1S,1'S)-((2R,3R)-oxirane-2,3-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→(2S,3S,5S)-2,5-diamino-1,6-diphenylhexan-3-ol→phenylboronic acid→(S)-1-((4S,6S)-4-benzyl-2-phenyl-1,3,2-oxazaborinan-6-yl)-2-phenylethanamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→ethyl 2-chloroacetate→ethyl 2-chloro-3-oxopropanoate→methanethioamide→ethyl thiazole-5-carboxylate→thiazol-5-ylmethanol→4-nitrophenyl carbonochloridate→isobutyramide→2-methylpropanethioamide→1,3-dichloropropan-2-one→methyl L-valinate hydrochloride→1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→RITO-025→(S)-methyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate
(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→(S)-benzyl (1-oxo-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→1-bromo-2-methyl-1-oxopropan-2-yl acetate→(5S,6R,7R,8S)-5,8-dibenzyl-7-bromo-3,10-dioxo-1,12-diphenyl-2,11-dioxa-4,9-diazadodecan-6-yl acetate→dibenzyl ((1S,1'S)-((2R,3R)-oxirane-2,3-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→(2S,3S,5S)-2,5-diamino-1,6-diphenylhexan-3-ol→phenylboronic acid→(S)-1-((4S,6S)-4-benzyl-2-phenyl-1,3,2-oxazaborinan-6-yl)-2-phenylethanamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→ethyl 2-chloroacetate→ethyl 2-chloro-3-oxopropanoate→methanethioamide→ethyl thiazole-5-carboxylate→thiazol-5-ylmethanol→4-nitrophenyl carbonochloridate→isobutyramide→2-methylpropanethioamide→1,3-dichloropropan-2-one→methyl L-valinate hydrochloride→1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→RITO-025→(S)-methyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(R)-quinuclidin-3-ol→4,4,5,5-tetramethyl-2-phenyl-1,3,2-dioxaborolane→ethyl(phenyl)zinc→3,4-dihydroisoquinoline 2-oxide→tert-butyl ((2S,3S)-3-methyl-1-morpholinopentan-2-yl)carbamate→(S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-ol→4-nitrophenyl carbonochloridate→4-nitrophenyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→4-(chloromethyl)-5-methyl-1,3-dioxol-2-one→(Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid→(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→4-nitrophenyl carbonochloridate→(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (Z)-2-ethoxy-1-((2'-(N'-(((4-nitrophenoxy)carbonyl)oxy)carbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
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