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CAS 82546-55-2
(2R,4R,5R,7S,10R,14S,15S,16S,18S)-5,7-Dihydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5'-one
登记编号：(XVIII)169995-1-b、(VIII)169995-5-a、(V)169995-23-a
应用背景（按来源药适应症）
避孕屈螺酮口腔炎，口疮屈螺酮经前焦虑性障碍屈螺酮经前期综合征屈螺酮痛经屈螺酮抑郁屈螺酮
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 屈螺酮Drospirenone | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1R,2R,4R,5R,10R,11S,14S,15S,16S,18S,19S)-5-Hydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5',7-dione→3-[3beta-[tert-Butyl(dimethyl)silyloxy]-5beta,17beta-dihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl]-2-propynoic acid ethyl ester→6beta,7beta:15beta,16beta-Dimethylene-3beta-t-butyldimethylsilyloxy-5beta,17beta-dihydroxy-17alpha-(2-ethoxycarbonyl)-ethyl-androstane→(2R,4R,5R,7S,10R,14S,15S,16S,18S)-5,7-Dihydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5'-one
(2S,3'S,5'S,7'S,11'R,14'S)-14'-hydroxy-7',11'-dimethylspiro[oxolane-2,6'-pentacyclo[8.8.0.0(2,7).0(3,5).0(11,16)]octadecan]-16'-en-5-one→(2S,3'S,5'S,7'S,11'R,14'S,18'R)-14',18'-dihydroxy-7',11'-dimethylspiro[oxolane-2,6'-pentacyclo[8.8.0.0(2,7).0(3,5).0(11,16)]octadecan]-16'-en-5-one→(2S,3'S,5'S,7'S,11'R,14'S,18'R)-14'-[(tert-butyldimethylsilyl)oxy]-18'-hydroxy-7',11'-dimethylspiro[oxolane-2,6'-pentacyclo[8.8.0.0(2,7).0(3,5).0(11,16)]octadecan]-16'-en-5-one→(2R,5S,7S,9R,10R,13S,15S,16S,17S)-5-[(tert-butyldimethylsilyl)oxy]-10-hydroxy-2,17-dimethyl-8-oxaspiro[hexacyclo[9.8.0.0(2,7).0(7,9).0(12,17).0(13,15)]nonadecane-16,2'-oxolane]-5'-one→(2R,5S,7S,9S,10S,13S,15S,16S,17S)-5-[(tert-butyldimethylsilyl)oxy]-10-chloro-2,17-dimethyl-8-oxaspiro[hexacyclo[9.8.0.0(2,7).0(7,9).0(12,17).0(13,15)]nonadecane-16,2'-oxolane]-5'-one→(2R,5S,7S,9S,10S,13S,15S,16S,17S)-10-chloro-5-hydroxy-2,17-dimethyl-8-oxaspiro[hexacyclo[9.8.0.0(2,7).0(7,9).0(12,17).0(13,15)]nonadecane-16,2'-oxolane]-5'-one→(2S,3'S,5'S,7'S,11'R,14'S,16'R)-14',16'-dihydroxy-7',11'-dimethylspiro[oxolane-2,6'-pentacyclo[8.8.0.0(2,7).0(3,5).0(11,16)]octadecan]-17'-en-5-one→(2R,4R,5R,7S,10R,14S,15S,16S,18S)-5,7-Dihydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5'-one
(2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,10aR)-2,10a-Dihydroxy-4a,6a-dimethyl-2,3,4,4a,4b,5,6,6a,7a,8,8a,8b,8c,10a-tetradecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7(1H)-one→(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→3-Bromopropionic acid methyl ester→Methyl 3-[(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-1b,3,8-trihydroxy-5a,7a-dimethyloctadecahydro-1H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-yl]propanoate→(1aR,1bR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bS,9cR,9dR)-8-(3-Hydroxypropyl)-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol→(2R,4R,5R,7S,10R,14S,15S,16S,18S)-5,7-Dihydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5'-one
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