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CAS 86483-52-5
cyclopropanamine
登记编号：LENT-013、TRAT-002、FINA-009、TELAP-021
应用背景（按来源药适应症）
肾细胞癌甲磺酸仑伐替尼子宫内膜癌甲磺酸仑伐替尼肝细胞癌甲磺酸仑伐替尼甲状腺瘤甲磺酸仑伐替尼甲状腺瘤曲美替尼胶质瘤曲美替尼毛细胞白血病曲美替尼甲状腺未分化癌曲美替尼实体瘤曲美替尼非小细胞肺癌曲美替尼外耳炎非那沙星分泌性中耳炎非那沙星中耳炎非那沙星泌尿系统感染非那沙星肾盂肾炎非那沙星革兰氏阴性细菌感染非那沙星丙型肝炎特拉匹韦慢性丙型肝炎特拉匹韦HIV感染特拉匹韦肝功能衰退特拉匹韦阿片类依赖特拉匹韦肾脏疾病特拉匹韦
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-amino-2-chlorobenzonitrile→4-amino-2-methoxybenzonitrile→5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione→4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid→4-chloro-7-methoxyquinoline-6-carbonyl chloride→4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide→phenyl carbonochloridate→phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate→cyclopropanamine
2-fluoro-4-iodoaniline→cyclopropanamine→1-cyclopropyl-3-(2-fluoro-4-iodophenyl)urea→2-cyanoacetic acid→2-cyano-N-cyclopropyl-N-((2-fluoro-4-iodophenyl)carbamoyl)acetamide→6-amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyrimidine-2,4(1H,3H)-dione→(E)-N'-(1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione→2-methylmalonic acid→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate→N-(3-aminophenyl)acetamide→N-(3-((3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
1-fluoro-3,5-dimethylbenzene→2,4-dichloro-1-fluoro-3,5-dimethylbenzene→2,4-dichloro-3-(dichloromethyl)-1-fluoro-5-(trichloromethyl)benzene→2,4-dichloro-5-fluoro-3-formylbenzoic acid→(Z)-2,4-dichloro-5-fluoro-3-((hydroxyimino)methyl)benzoic acid→2,4-dichloro-3-cyano-5-fluorobenzoyl chloride→(Z)-ethyl 3-(dimethylamino)acrylate→ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate→cyclopropanamine→ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate→ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate→7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→(4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazine→(E)-but-2-ene-1,4-diol→1-tosyl-2,5-dihydro-1H-pyrrole→3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane→2-aminoethan-1-ol→4-((2-hydroxyethyl)amino)-1-tosylpyrrolidin-3-ol→2-(N-(4-hydroxy-1-tosylpyrrolidin-3-yl)-4-methylphenylsulfonamido)ethyl 4-methylbenzenesulfonate→4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine→(4aS,7aS)-4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine
2,4-dichloro-3-cyano-5-fluorobenzoyl chloride→(Z)-ethyl 3-(dimethylamino)acrylate→ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate→cyclopropanamine→ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate→ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate→(E)-but-2-ene-1,4-diol→1-tosyl-2,5-dihydro-1H-pyrrole→3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane→2,4-dichloro-1-fluorobenzene→1-(2,4-dichloro-5-fluorophenyl)ethanone→2,4-dichloro-5-fluorobenzoic acid→2,4-dichloro-5-fluoro-3-nitrobenzoic acid→methyl 2,4-dichloro-5-fluoro-3-nitrobenzoate→methyl 3-amino-2,4-dichloro-5-fluorobenzoate→methyl 2,4-dichloro-3-cyano-5-fluorobenzoate→2,4-dichloro-3-cyano-5-fluorobenzoic acid→(4aS,7aS)-tert-butyl hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate→(4aS,7aS)-tert-butyl 6-(8-cyano-1-cyclopropyl-3-(ethoxycarbonyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate→7-((4aS,7aS)-4-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→(E)-1,4-dichlorobut-2-ene→(R)-1-phenylethan-1-amine→(3S,4S)-4-(((R)-1-phenylethyl)amino)-1-tosylpyrrolidin-3-ol→2-chloroacetyl chloride→2-chloro-N-((3S,4S)-4-hydroxy-1-tosylpyrrolidin-3-yl)-N-((R)-1-phenylethyl)acetamide→(4aS,7aS)-4-((R)-1-phenylethyl)-6-tosylhexahydropyrrolo[3,4-b][1,4]oxazin-3(2H)-one→(4aS,7aS)-4-((R)-1-phenylethyl)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine→(4aS,7aS)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine→(4aS,7aS)-tert-butyl 6-tosylhexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate
(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid→(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide→(E)-hex-2-en-1-ol→((2R,3S)-3-propyloxiran-2-yl)methanol→(2S,3S)-3-propyloxirane-2-carboxylic acid→cyclopropanamine→(2S,3S)-N-cyclopropyl-3-propyloxirane-2-carboxamide→(2S,3S)-3-azido-N-cyclopropyl-2-hydroxyhexanamide→(2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride→(1S,3aR,6aS)-2-benzyloctahydrocyclopenta[c]pyrrole-1-carboxylic acid→(1S,3aR,6aS)-2-benzyl-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide→(1S,3aR,6aS)-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
pyrazine-2-carboxylic acid→cyclopropanamine→1-nitrobutane→2-oxoacetic acid→(3S)-2-hydroxy-3-nitrohexanoic acid→(3S)-3-amino-2-hydroxyhexanoic acid→(3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxyhexanoic acid→(S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-oxohexanoic acid→TELAP-046→TELAP-047→(1S,3aR,6aS)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid→TELAP-049→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid→TELAP-051→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclohexylacetic acid→TELAP-053→TELAP-054→(S)-3-((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxamido)-2-oxohexanoic acid
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 4-Chloro-7-methoxyquinoline -6-carboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 4-Chloro-7-methoxyquinoline -6-carboxamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | N-(2-Chloro-4-hydroxyphenyl)-N'-cyclopropyl-urea Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 4-Amino-3-chlorophenol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。