← 返回专利悬崖列表
CAS 87417-71-8
4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine
登记编号：GAND-016、GAND-017
应用背景（按来源药适应症）
血液肿瘤Gandotinib骨髓纤维化Gandotinib骨髓增生性疾病Gandotinib原发性血小板增多症Gandotinib真性红细胞增多症Gandotinib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Gandotinib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
6-chloropyridazin-3-amine→4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine→ethyl 2-chloro-3-oxobutanoate→ethyl 6-chloro-2-methylimidazo[1,2-b]pyridazine-3-carboxylate→ethyl 6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazine-3-carboxylate→4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine→4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine
(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide→2-chloro-1-(4-chloro-2-fluorophenyl)ethanone→(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanone→(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone→4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine→2-(1,3-dioxoisoindolin-2-yl)acetic acid→2-((6-chloro-3-(4-chloro-2-fluorobenzoyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)isoindoline-1,3-dione→(8-(aminomethyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)(4-chloro-2-fluorophenyl)methanone→1-bromo-2-(2-bromoethoxy)ethane→(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol→1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-amine→3-(4-chloro-2-fluorobenzyl)-N-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-yl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine→tert-butyl hydrazinecarboxylate→4-methoxybenzaldehyde→tert-butyl 2-(4-methoxybenzyl)hydrazinecarboxylate→tert-butyl 2-(4-methoxybenzyl)hydrazinecarboxylate→(4-methoxybenzyl)hydrazine→3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。