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CAS 921-01-7
(S)-2-amino-3-mercaptopropanoic acid
登记编号：ETEL-011
应用背景（按来源药适应症）
继发性甲状旁腺功能亢进症盐酸依特卡肽慢性肾功能不全盐酸依特卡肽终末期肾脏病盐酸依特卡肽心源性水肿盐酸依特卡肽
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸依特卡肽Etelcalcetide Hydrochloride | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(R)-2-amino-N-methyl-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-amino-N-methyl-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-((R)-2-aminopropanamido)-N-methyl-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-amino-N-((R)-1-(((R)-1-(methylamino)-1-oxo-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentan-2-yl)amino)-1-oxopropan-2-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-amino-N-((6R,9R,12R)-1,17-diimino-9-methyl-6-(methylcarbamoyl)-8,11-dioxo-1,17-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-2,7,10,16-tetraazaheptadecan-12-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-amino-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-((R)-2-aminopropanamido)-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-((R)-2-((R)-2-amino-3-(tritylthio)propanamido)propanamido)-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-((R)-2-((R)-2-acetamido-3-(tritylthio)propanamido)propanamido)-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide→(R)-2-((R)-2-((R)-2-acetamido-3-(pyridin-2-yldisulfanyl)propanamido)propanamido)-N-((6R,9R,12R,15R)-1,20-diamino-6-carbamoyl-12-(3-guanidinopropyl)-1,20-diimino-9-methyl-8,11,14-trioxo-2,7,10,13,19-pentaazaicosan-15-yl)-5-guanidinopentanamide→(S)-2-amino-3-mercaptopropanoic acid
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