甲苯磺酸卢美哌隆

Tier C — Watch / trade

Lumateperone tosylate · all drugs expiring in 2031 →

百时美施贵宝

Originator

2019

First approval

2031

Expiry (public)

$0.7B ▲

Peak sales

化学药

Type

Targets：5-HT2A、DRD2

Brand：Caplyta、CAPLYTA

Indications (approved)：重度抑郁症、抑郁、精神分裂症

Regional status

批准上市

2019-12-20

临床三期

2016-03-07

China

临床三期

2025-08-27

Japan

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield /

Code	CAS No.	Intermediate
LUMAT-001	59564-59-9 Available	3,4-dihydroquinoxalin-2(1H)-one
LUMAT-002	53374-52-0 Available	4-nitroso-3,4-dihydroquinoxalin-2(1H)-one
LUMAT-003	29976-53-2 Available	ethyl 4-oxopiperidine-1-carboxylate
LUMAT-004	313544-31-9 Available	ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
LUMAT-005	313369-16-3 Available	(6bR,10aS)-ethyl 2-oxo-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
LUMAT-006	313369-25-4 Available	(6bR,10aS)-ethyl 3-methyl-2-oxo-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
LUMAT-007	313369-26-5 Available	(6bR,10aS)-ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
LUMAT-008	313368-85-3 Available	(6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
LUMAT-009	3874-54-2 Available	4-chloro-1-(4-fluorophenyl)butan-1-one

Frequently asked questions

What are the approved indications of Lumateperone tosylate?

Approved indications include: 重度抑郁症, 抑郁, 精神分裂症.

When does the Lumateperone tosylate patent expire?

Based on public sources, the Lumateperone tosylate patent expires in 2031.

How many synthesis routes are recorded for Lumateperone tosylate?

1 synthesis routes are recorded; the shortest is 7 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Lumateperone tosylate intermediates?

9 intermediate CAS of Lumateperone tosylate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Lumateperone tosylate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24