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富马酸伏诺拉生

Tier C — Watch / trade

Vonoprazan Fumarate

武田药品工业株式会社
Originator
2014
First approval
-
Expiry (public)
$0.96B ▲
Peak sales
化学药
Type

Targets：H+/K+ ATPase

Brand：Vonosap pack 400、Vocinti、Vonopion pack、沃克、Takecab、Voquezna、Vonosap pack 800

Indications (approved)：幽门螺杆菌感染、食管炎、胃食管反流病、胃灼痛、消化性食管炎、螺杆菌感染、十二指肠溃疡、胃溃疡

Regional status

US
批准上市
2023-11-01
EU
无进展
2008-10-01
China
批准上市
2019-12-18
Japan
批准上市
2014-12-26

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 10 · Total yield 912 mg
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
VONO-001445-27-2Available1-(2-fluorophenyl)ethanone
VONO-002655-15-2Available2-bromo-1-(2-fluorophenyl)ethanone
VONO-003105-56-6Availableethyl 2-cyanoacetate
VONO-004881673-98-9Availableethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate
VONO-005881674-01-7Availableethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate
VONO-006881674-06-2Availableethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate
VONO-007881674-58-4Available(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol
VONO-008881674-56-2Available5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
VONO-00942899-76-3Availablepyridine-3-sulfonyl chloride hydrochloride
VONO-010881677-11-8Available5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
VONO-011110-17-8Availablefumaric acid
VONO-012636-73-7Availablepyridine-3-sulfonic acid
OptimisedRoute 2Steps 5 · Total yield 20.7 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
VONO-008881674-56-2Available5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
VONO-011110-17-8Availablefumaric acid
VONO-0131610043-62-3Available1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine
VONO-0141610043-63-4Availabletert-butyl ((5-(2-fluorophenyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate
VONO-01516133-25-8Availablepyridine-3-sulfonyl chloride
VONO-0161831110-76-9Availabletert-butyl ((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate
OptimisedRoute 3Steps 6 · Total yield 7.57 g
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
VONO-001445-27-2Available1-(2-fluorophenyl)ethanone
VONO-002655-15-2Available2-bromo-1-(2-fluorophenyl)ethanone
VONO-010881677-11-8Available5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
VONO-01516133-25-8Availablepyridine-3-sulfonyl chloride
VONO-017-2-(2-fluorobenzoyl)malononitrile
VONO-018-2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
VONO-019881674-56-2Available5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
Vonoprazan Fumarate1260141-27-2Available-
OptimisedRoute 4Steps 3 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
VONO-0201240948-77-9Available5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
VONO-01516133-25-8Availablepyridine-3-sulfonyl chloride
VONO-0211807642-39-2Available5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbonitrile
VONO-0221807642-41-6Available(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methanamine

Frequently asked questions

What are the approved indications of Vonoprazan Fumarate?

Approved indications include: 幽门螺杆菌感染, 食管炎, 胃食管反流病, 胃灼痛, 消化性食管炎, 螺杆菌感染, 十二指肠溃疡, 胃溃疡.

When does the Vonoprazan Fumarate patent expire?

No public expiry year is available for Vonoprazan Fumarate yet; this page updates once verified.

How many synthesis routes are recorded for Vonoprazan Fumarate?

4 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Vonoprazan Fumarate intermediates?

20 intermediate CAS of Vonoprazan Fumarate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Vonoprazan Fumarate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24