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CAS 105-56-6
ethyl 2-cyanoacetate2-Cyanoacetic acid ethyl ester
Codes：TOFA-009、AVAN-034、VONO-003、ETRA-015、Cefoselis Sulfate-012
Application context (from source-drug indications)
强直性脊柱炎枸橼酸托法替布幼年型类风湿性关节炎枸橼酸托法替布溃疡性结肠炎枸橼酸托法替布银屑病关节炎枸橼酸托法替布类风湿关节炎枸橼酸托法替布勃起功能障碍阿伐那非消化性溃疡出血醋酸伏诺拉生幽门螺杆菌感染富马酸伏诺拉生食管炎富马酸伏诺拉生胃食管反流病富马酸伏诺拉生胃灼痛富马酸伏诺拉生消化性食管炎富马酸伏诺拉生螺杆菌感染富马酸伏诺拉生HIV感染依曲韦林弗里德赖希共济失调依曲韦林炎性疾病依曲韦林胰岛素抵抗依曲韦林细菌感染硫酸头孢噻利
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-benzyl-N,4-dimethylpiperidin-3-amine→4-chloro-7H-pyrrolo[2,3-d]pyrimidine→N-(1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→4-chloro-7-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine→N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→ethyl 2-cyanoacetate
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine hemi((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate)→2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine→N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→1-benzyl-N,4-dimethylpiperidin-3-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→ethyl 2-cyanoacetate→methyl (4-methylpyridin-3-yl)carbamate→1-benzyl-3-((methoxycarbonyl)amino)-4-methylpyridin-1-ium chloride→methyl (1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamate
(S)-pyrrolidin-2-ylmethanol→ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate→pyrimidin-2-ylmethanamine→ethyl 2-cyanoacetate→urea→ethyl (E)-2-cyano-3-ureidoacrylate→ethyl 6-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylate→2-chloro-4-(chloromethyl)-1-methoxybenzene→ethyl 6-((3-chloro-4-methoxybenzyl)amino)-2-oxo-1,2-dihydropyrimidine-5-carboxylate
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
4-hydroxy-3,5-dimethylbenzonitrile→1-(4-cyanophenyl)guanidine hydrochloride→ethyl 2-cyanoacetate→4-((4-amino-6-hydroxypyrimidin-2-yl)amino)benzonitrile→4-((4-amino-6-chloropyrimidin-2-yl)amino)benzonitrile→N-(6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide→N-(5-bromo-6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide→N-(5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide
2-(5-Amino-1H-pyrazol-1-yl)ethan-1-ol→N,N-Dimethylformamide→2-Cyanoacetic acid methyl ester→2-Cyanoacetic acid ethyl ester→Propyl cyanoacetate→Butyl cyanoacetate→Methyl 2-cyano-3-(dimethylamino)prop-2-enoate→Ethyl 2-cyano-3-(dimethylamino)prop-2-enoate→Propyl 2-cyano-3-(dimethylamino)prop-2-enoate→Butyl 2-cyano-3-(dimethylamino)prop-2-enoate→2-Hydrazinoethanol→Methyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Ethyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Propyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Butyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→5-Amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylic acid→Hex-3-enedinitrile→But-3-enenitrile→3-Oxopropanenitrile→3,3-Dimethoxypropanenitrile→3-[2-(2-Hydroxyethyl)hydrazinylidene]propanenitrile
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | （3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCL Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 1-benzyl-4-methylpiperidin-3-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | pyridine-3-sulfonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | Vonoprazan Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 3-Pyridinesulfonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.