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Tier C — Watch / tradeTopiroxostat
Targets：XO
Brand：Uriadec、Topiloric
Indications (approved)：高尿酸血症、痛风
Regional status
Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| TOPI-001 | 13602-12-5 | 4-carboxypyridine 1-oxide |
| TOPI-002 | 3783-38-8 | 4-(methoxycarbonyl)pyridine 1-oxide |
| TOPI-003 | 94413-64-6 | methyl 2-cyanoisonicotinate |
| TOPI-004 | 135048-32-7 | 2-cyanoisonicotinohydrazide |
| TOPI-005 | 100-48-1 | isonicotinonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| TOPI-006 | 14906-59-3 | 4-cyanopyridine 1-oxide |
| TOPI-007 | 54-85-3 | isonicotinohydrazide |
| TOPI-008 | 79-44-7 | dimethylcarbamic chloride |
| TOPI-009 | 79-44-7 | dimethylcarbamic chloride |
| TOPI-010 | 1041845-96-8 | 5-(2-cyanopyridin-4-yl)-N,N-dimethyl-3-(pyridin-4-yl)-1H-1,2,4-triazole-1-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| TOPI-001 | 13602-12-5 | 4-carboxypyridine 1-oxide |
| TOPI-005 | 100-48-1 | isonicotinonitrile |
| TOPI-011 | 577778-86-0 | 4-(2-(tert-butoxycarbonyl)hydrazinecarbonyl)pyridine 1-oxide |
| TOPI-012 | 1207715-20-5 | tert-butyl 2-(2-cyanoisonicotinoyl)hydrazinecarboxylate |
| TOPI-013 | 135048-32-7 | 2-cyanoisonicotinohydrazide |
| Code | CAS No. | Intermediate |
|---|---|---|
| TOPI-003 | 94413-64-6 | methyl 2-cyanoisonicotinate |
| TOPI-004 | 135048-32-7 | 2-cyanoisonicotinohydrazide |
| TOPI-005 | 100-48-1 | isonicotinonitrile |
| TOPI-014 | 2459-09-8 | methyl isonicotinate |
| TOPI-015 | 1379342-46-7 | methyl 2-carbamoylisonicotinate |
Frequently asked questions
What are the approved indications of Topiroxostat?
Approved indications include: 高尿酸血症, 痛风.
When does the Topiroxostat patent expire?
No public expiry year is available for Topiroxostat yet; this page updates once verified.
How many synthesis routes are recorded for Topiroxostat?
4 synthesis routes are recorded; the shortest is 4 steps with 3.66 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Topiroxostat intermediates?
All intermediates in Topiroxostat routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Topiroxostat intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24