CAS 100-48-1

isonicotinonitrile

Codes：TOPI-005、DALF-006

Application context (from source-drug indications)

高尿酸血症托匹司他痛风托匹司他糖尿病肾病托匹司他多发性硬化达伐吡啶脊髓小脑共济失调达伐吡啶短时记忆达伐吡啶挤压伤达伐吡啶周围神经损伤达伐吡啶脊髓损伤达伐吡啶

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
托匹司他Topiroxostat	Tier C — Watch / trade	-
达伐吡啶Dalfampridine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

托匹司他原研路线steps: 4total yield: 3.66 g

4-carboxypyridine 1-oxide→4-(methoxycarbonyl)pyridine 1-oxide→methyl 2-cyanoisonicotinate→2-cyanoisonicotinohydrazide→isonicotinonitrile

托匹司他优化路线steps: 4total yield: /

4-carboxypyridine 1-oxide→isonicotinonitrile→4-(2-(tert-butoxycarbonyl)hydrazinecarbonyl)pyridine 1-oxide→tert-butyl 2-(2-cyanoisonicotinoyl)hydrazinecarboxylate→2-cyanoisonicotinohydrazide

托匹司他优化路线steps: 4total yield: 19 g

methyl 2-cyanoisonicotinate→2-cyanoisonicotinohydrazide→isonicotinonitrile→methyl isonicotinate→methyl 2-carbamoylisonicotinate

达伐吡啶优化路线steps: 1total yield: 8.2 g

isonicotinonitrile

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