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阿来替尼盐酸盐

Tier B — Position early

Alectinib Hydrochloride · all drugs expiring in 2030 →

中外制药株式会社
Originator
2014
First approval
2030
Expiry (public)
$1.89B ▲
Peak sales
化学药
Type

Targets：ALK、RET

Brand：Alecensa、Alecensaro

Indications (approved)：非小细胞肺癌、肺癌

Regional status

US
批准上市
2015-12-11
EU
批准上市
2017-02-16
China
批准上市
2018-08-12
Japan
批准上市
2014-07-04

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 10 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
ALEC-0014133-34-0Available7-methoxy-3,4-dihydronaphthalen-2(1H)-one
ALEC-0021865-83-4Available7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
ALEC-0031256578-99-0Available6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
ALEC-00417672-26-3Available3-hydrazinylbenzonitrile
ALEC-0051256579-00-6Available9-bromo-8-methoxy-6,6-dimethyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-0061256579-03-9Available9-bromo-8-methoxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-0071256579-06-2Available9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-0081256579-48-2Available9-bromo-3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl trifluoromethanesulfonate
ALEC-00953617-35-9Available4-(piperidin-4-yl)morpholine
ALEC-0101256579-62-0Available9-bromo-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-01189343-06-6Availableethynyltriisopropylsilane
ALEC-0121256580-24-1Available9-ethynyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
OptimisedRoute 2Steps 9 · Total yield 357 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
ALEC-00953617-35-9Available4-(piperidin-4-yl)morpholine
ALEC-01332454-35-6Available2-(4-bromophenyl)-2-methylpropanoic acid
ALEC-01413682-77-4Availablepotassium trifluoro(vinyl)borate
ALEC-0151256584-72-1Available2-methyl-2-(4-vinylphenyl)propanoic acid
ALEC-0161247119-83-0Available2-(4-ethylphenyl)-2-methylpropanoic acid
ALEC-0171256584-73-2Available2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid
ALEC-01840052-13-9Available3-(tert-butoxy)-3-oxopropanoic acid
ALEC-0191256584-74-3Availabletert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate
ALEC-020939-80-0Available4-chloro-3-nitrobenzonitrile
ALEC-0211256584-75-4Availabletert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate
ALEC-0221256698-41-5Availabletert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate hydrochloride
ALEC-0231256584-78-7Available6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid
OptimisedRoute 3Steps 6 · Total yield 2.1 g
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
ALEC-00953617-35-9Available4-(piperidin-4-yl)morpholine
ALEC-0231256584-78-7Available6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid
ALEC-02490841-42-2Available1-(3-bromo-4-ethylphenyl)ethanone
ALEC-0251675897-35-4Available1-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)ethanone
ALEC-0261675897-39-8Available2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-ol
ALEC-0271357147-38-6Availablemethyl 6-cyano-1H-indole-3-carboxylate
ALEC-0281675897-18-3Availablemethyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate
ALEC-02915861-36-6Available1H-indole-6-carbonitrile
ALEC-03076-02-8Available2,2,2-trichloroacetyl chloride

Frequently asked questions

What are the approved indications of Alectinib Hydrochloride?

Approved indications include: 非小细胞肺癌, 肺癌.

When does the Alectinib Hydrochloride patent expire?

Based on public sources, the Alectinib Hydrochloride patent expires in 2030.

How many synthesis routes are recorded for Alectinib Hydrochloride?

3 synthesis routes are recorded; the shortest is 6 steps with 2.1 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Alectinib Hydrochloride intermediates?

30 intermediate CAS of Alectinib Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Alectinib Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24