CAS 53617-35-9

4-(piperidin-4-yl)morpholine

Codes：ALEC-009

Application context (from source-drug indications)

非小细胞肺癌阿来替尼盐酸盐肺癌阿来替尼盐酸盐

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
阿来替尼盐酸盐Alectinib Hydrochloride	Tier B — Position early	2030

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿来替尼盐酸盐原研路线steps: 10total yield: /

7-methoxy-3,4-dihydronaphthalen-2(1H)-one→7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one→6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one→3-hydrazinylbenzonitrile→9-bromo-8-methoxy-6,6-dimethyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile→9-bromo-8-methoxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile→9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile→9-bromo-3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl trifluoromethanesulfonate→4-(piperidin-4-yl)morpholine→9-bromo-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile→ethynyltriisopropylsilane→9-ethynyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

阿来替尼盐酸盐优化路线steps: 9total yield: 357 g

4-(piperidin-4-yl)morpholine→2-(4-bromophenyl)-2-methylpropanoic acid→potassium trifluoro(vinyl)borate→2-methyl-2-(4-vinylphenyl)propanoic acid→2-(4-ethylphenyl)-2-methylpropanoic acid→2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid→3-(tert-butoxy)-3-oxopropanoic acid→tert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate→4-chloro-3-nitrobenzonitrile→tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate→tert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate hydrochloride→6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid

阿来替尼盐酸盐优化路线steps: 6total yield: 2.1 g

4-(piperidin-4-yl)morpholine→6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid→1-(3-bromo-4-ethylphenyl)ethanone→1-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)ethanone→2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-ol→methyl 6-cyano-1H-indole-3-carboxylate→methyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate→1H-indole-6-carbonitrile→2,2,2-trichloroacetyl chloride

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-(piperidin-4-yl)morpholine Pharmaceutical Intermediates	询价	询价	询价	—

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