泽布替尼
Tier A — Act nowZanubrutinib · all drugs expiring in 2031 →
Targets：BTK
Brand：Brukinsa、百悦泽
Indications (approved)：华氏巨球蛋白血症、慢性淋巴细胞白血病、滤泡性淋巴瘤、边缘带B细胞淋巴瘤、套细胞淋巴瘤
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ZANU-001 | 2215-77-2Available | 4-phenoxybenzoic acid |
| ZANU-002 | 1623-95-6 | 4-phenoxybenzoyl chloride |
| ZANU-003 | 330792-68-2 | 2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile |
| ZANU-004 | 330792-69-3 | 2-(methoxy(4-phenoxyphenyl)methylene)malononitrile |
| ZANU-005 | 330792-70-6Available | 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile |
| ZANU-006 | 960201-86-9 | (Z)-tert-butyl 4-(3-(dimethylamino)acryloyl)piperidine-1-carboxylate |
| ZANU-007 | 2190506-55-7 | tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate |
| ZANU-008 | 2190506-56-8 | tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate |
| ZANU-009 | 1633350-03-4 | tert-butyl 4-(3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate |
| ZANU-010 | 1633350-05-6 | 2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2,2,2-trifluoroacetate |
| ZANU-011 | 1633350-06-7 | 7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide |
| Zanubrutinib | 1691249-45-2 | (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide |
Frequently asked questions
What are the approved indications of Zanubrutinib?
Approved indications include: 华氏巨球蛋白血症, 慢性淋巴细胞白血病, 滤泡性淋巴瘤, 边缘带B细胞淋巴瘤, 套细胞淋巴瘤.
When does the Zanubrutinib patent expire?
Based on public sources, the Zanubrutinib patent expires in 2031.
How many synthesis routes are recorded for Zanubrutinib?
1 synthesis routes are recorded; the shortest is 10 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Zanubrutinib intermediates?
2 intermediate CAS of Zanubrutinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Zanubrutinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24