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CAS 330792-69-3
2-(methoxy(4-phenoxyphenyl)methylene)malononitrile1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene
Codes：IBRT-003、(IV)461018-3-a、(V)461018-25-a、ZANU-004
Application context (from source-drug indications)
华氏巨球蛋白血症伊布替尼慢性淋巴细胞白血病伊布替尼套细胞淋巴瘤伊布替尼移植物抗宿主病伊布替尼华氏巨球蛋白血症泽布替尼慢性淋巴细胞白血病泽布替尼滤泡性淋巴瘤泽布替尼边缘带B细胞淋巴瘤泽布替尼套细胞淋巴瘤泽布替尼
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-phenoxybenzoic acid→2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile→2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(S)-tert-butyl 3-hydroxypiperidine-1-carboxylate→(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→acryloyl chloride→1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→tert-butyl 4-(((6-amino-5-chloropyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→4-phenoxybenzoyl chloride→(R)-1-(3-hydrazinylpiperidin-1-yl)prop-2-en-1-one→(R)-1-(1-acryloylpiperidin-3-yl)-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→(4-Phenoxybenzoyl)malononitrile→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→1-[(3R)-3-Hydrazinopiperidin-1-yl]prop-2-en-1-one→1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→(Dimethylamino)formaldehyde dimethyl acetal
(3R)-3-Amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)(nitroso)amino]piperidine-1-carboxylate→tert-Butyl (3R)-3-[1-(tert-butoxycarbonyl)hydrazinyl]piperidine-1-carboxylate→(3R)-3-Hydrazinylpiperidine→Amide c1→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→5-Amino-3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazole-4-carbonitrile→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbaldehyde→2-Propenoyl chloride→3-Aminopiperidine→5-Oxo-D-proline (3R)-piperidin-3-amine→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate
4-phenoxybenzoic acid→4-phenoxybenzoyl chloride→2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile→2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→(Z)-tert-butyl 4-(3-(dimethylamino)acryloyl)piperidine-1-carboxylate→tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate→tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate→tert-butyl 4-(3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate→2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2,2,2-trifluoroacetate→7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide→(S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
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