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艾托格列净

Tier C — Watch / trade

Ertugliflozin

辉瑞
Originator
2017
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type

Targets：SGLT2

Brand：捷诺妥、Steglatro

Indications (approved)：二型糖尿病

Regional status

US
批准上市
2017-12-19
EU
批准上市
2018-03-21
China
批准上市
2020-07-29
Japan
-

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 13 · Total yield 60 mg
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
ERTU-0012280-44-6Available(3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
ERTU-00254606-68-7Available((2R,3R,4S,5R)-6-(allyloxy)-3,4,5-tris(benzyloxy)tetrahydro-2H-pyran-2-yl)methanol
ERTU-0031210344-25-4Available((3S,4S,5R)-6-(allyloxy)-3,4,5-tris(benzyloxy)tetrahydro-2H-pyran-2,2-diyl)dimethanol
ERTU-0042746-25-0Available1-(bromomethyl)-4-methoxybenzene
ERTU-0051210344-28-7Available(3S,4S,5R)-6-(allyloxy)-3,4,5-tris(benzyloxy)-2,2-bis(((4-methoxybenzyl)oxy)methyl)tetrahydro-2H-pyran
ERTU-0061210344-29-8Available(3R,4S,5S)-3,4,5-tris(benzyloxy)-6,6-bis(((4-methoxybenzyl)oxy)methyl)tetrahydro-2H-pyran-2-ol
ERTU-0071210344-30-1Available(3R,4S,5S)-3,4,5-tris(benzyloxy)-6,6-bis(((4-methoxybenzyl)oxy)methyl)tetrahydro-2H-pyran-2-one
ERTU-0086638-79-5AvailableN,O-dimethylhydroxylamine hydrochloride
ERTU-0091210344-31-2Available(2R,3S,4S)-2,3,4-tris(benzyloxy)-5-hydroxy-N-methoxy-6-((4-methoxybenzyl)oxy)-5-(((4-methoxybenzyl)oxy)methyl)-N-methylhexanamide
ERTU-010461432-23-5Available4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene
ERTU-0111210344-39-0Available(4S,5S)-3,4,5-tris(benzyloxy)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(((4-methoxybenzyl)oxy)methyl)tetrahydro-2H-pyran-2-ol
ERTU-0121210763-25-9Available((2S,3S)-2,3,4-tris(benzyloxy)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octan-1-yl)methanol
OptimisedRoute 3Steps 16 · Total yield 491 mg
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
ERTU-01914131-84-1Available(3aS,4S,6R,6aS)-6-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol
ERTU-020108678-46-2Availabletert-butyl(((3aS,4R,6R,6aS)-6-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)oxy)dimethylsilane
ERTU-021111000-75-0Available(R)-1-((3aS,4R,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethane-1,2-diol
ERTU-022111000-76-1Available(3aS,4S,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbaldehyde
ERTU-0231233481-95-2Available2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1,3-dithiane
ERTU-0241233481-96-3Available(R)-((3aS,4R,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)(2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1,3-dithian-2-yl)methanol
ERTU-0251233481-98-5Available(3aS,4S,6R,6aS)-6-((R)-(2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1,3-dithian-2-yl)(hydroxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol
ERTU-0261233481-99-6Available(3aS,6R,6aS)-6-((R)-(2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1,3-dithian-2-yl)(hydroxy)methyl)-3a-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol
ERTU-0271233482-00-2Available(1R,2R)-1-((S)-5,5-bis(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1,3-dithian-2-yl)ethane-1,2-diol
ERTU-0286342-60-5Available2-chloro-5-methylbenzoic acid
ERTU-029103-73-1Availableethoxybenzene
ERTU-0301275583-49-7Available(2-chloro-5-methylphenyl)(4-ethoxyphenyl)methanone
ERTU-0311275583-51-1Available(5-(bromomethyl)-2-chlorophenyl)(4-ethoxyphenyl)methanone
ERTU-0321275583-52-2Available4-(bromomethyl)-1-chloro-2-(4-ethoxybenzyl)benzene
ERTU-0331518795-13-5Available4-chloro-3-(4-ethoxybenzyl)benzyl acetate
ERTU-0341275583-53-3Available(4-chloro-3-(4-ethoxybenzyl)phenyl)methanol
ERTU-0351275583-54-4Available4-chloro-3-(4-ethoxybenzyl)benzaldehyde
ERTU-036109-80-8Availablepropane-1,3-dithiol
OptimisedRoute 4Steps 14 · Total yield 5.26 g
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
ERTU-03759531-24-7Available(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
ERTU-03813096-62-3Available(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one
ERTU-039109-01-3Available1-methylpiperazine
ERTU-0401431329-04-2Available(2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl)hexan-1-one
ERTU-0411520112-88-2Available(2R,3S,4S)-2,3,4,6-tetrakis(benzyloxy)-1-(4-methylpiperazin-1-yl)hexane-1,5-dione
ERTU-04253064-79-2Availableiodomethyl pivalate
ERTU-043-(3S,4S,5R)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-2-hydroxy-6-(4-methylpiperazin-1-yl)-6-oxohexyl pivalate
ERTU-044-(2R,3S,4S)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-5-(hydroxymethyl)-1-(4-methylpiperazin-1-yl)hexan-1-one
ERTU-0451431329-06-4Available(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one oxalate
ERTU-0461431329-05-3Available(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one
ERTU-0471298086-15-3Available2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene
ERTU-0481520113-20-5Available(2R,3S,4S)-2,3,4-tris(benzyloxy)-1-(3-((benzyloxy)(4-ethoxyphenyl)methyl)-4-chlorophenyl)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)butan-1-one
ERTU-0491629222-50-9Available(2S,3S,4R)-2,3,4-tris(benzyloxy)-1-((benzyloxy)methyl)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane
ERTU-0501298086-18-6Available(1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate
ProcessRoute 2Steps 8 · Total yield 9.59 kg
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
ERTU-010461432-23-5Available4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene
ERTU-01332384-65-9Available(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
ERTU-014714269-57-5Available(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
ERTU-0151528636-29-4Available((2R,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol
ERTU-0161528636-33-0Available(2S,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde
ERTU-0171528636-39-6Available(2S,3R,4S,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
ERTU-01898-79-3Available(S)-5-oxopyrrolidine-2-carboxylic acid

Frequently asked questions

What are the approved indications of Ertugliflozin?

Approved indications include: 二型糖尿病.

When does the Ertugliflozin patent expire?

No public expiry year is available for Ertugliflozin yet; this page updates once verified.

How many synthesis routes are recorded for Ertugliflozin?

4 synthesis routes are recorded; the shortest is 8 steps with 9.59 kg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ertugliflozin intermediates?

48 intermediate CAS of Ertugliflozin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ertugliflozin intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24