沃塞洛托

Tier C — Watch / trade

Voxelotor

Global Blood Therapeutics Inc

Originator

2019

First approval

Expiry (public)

$0.33B ▲

Peak sales

化学药

Type

Targets：Sickle haemoglobin

Brand：Oxbryta

Indications (approved)：镰状细胞血症、溶血性贫血

Regional status

撤市

批准上市

2022-02-14

China

Japan

Synthetic routes & intermediates2 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 15.3 g

Code	CAS No.	Intermediate
GTx-011-001	1282518-60-8 Available	1-isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
GTx-011-002	42330-59-6 Available	(2-chloropyridin-3-yl)methanol
GTx-011-003	1446321-93-2 Available	(2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methanol
GTx-011-004	1446395-78-3 Available	3-(chloromethyl)-2-(1-isopropyl-1H-pyrazol-5-yl)pyridine
GTx-011-005	84290-49-3 Available	2-hydroxy-6-(methoxymethoxy)benzaldehyde
GTx-011-006	1667717-42-1 Available	2-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-6-(methoxymethoxy)benzaldehyde
GTx-011-007	6751-75-3 Available	2-bromobenzene-1,3-diol
GTx-011-008	637329-14-7 Available	2-bromo-1,3-bis(methoxymethoxy)benzene
GTx-011-009	79834-12-1 Available	2,6-bis(methoxymethoxy)benzaldehyde

OptimisedRoute 2Steps 1 · Total yield 40 g

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
GTx-011-003	1446321-93-2 Available	(2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methanol
GTx-011-010	387-46-2 Available	2,6-dihydroxybenzaldehyde

Frequently asked questions

What are the approved indications of Voxelotor?

Approved indications include: 镰状细胞血症, 溶血性贫血.

When does the Voxelotor patent expire?

No public expiry year is available for Voxelotor yet; this page updates once verified.

How many synthesis routes are recorded for Voxelotor?

2 synthesis routes are recorded; the shortest is 1 steps with 40 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Voxelotor intermediates?

10 intermediate CAS of Voxelotor are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Voxelotor intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24