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CAS 1446395-78-3
3-(chloromethyl)-2-(1-isopropyl-1H-pyrazol-5-yl)pyridine
Codes：GTx-011-004
Application context (from source-drug indications)
镰状细胞血症沃塞洛托溶血性贫血沃塞洛托肾病沃塞洛托腿溃疡沃塞洛托急性肺损伤沃塞洛托间质性肺疾病沃塞洛托
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 沃塞洛托Voxelotor | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→(2-chloropyridin-3-yl)methanol→(2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methanol→3-(chloromethyl)-2-(1-isopropyl-1H-pyrazol-5-yl)pyridine→2-hydroxy-6-(methoxymethoxy)benzaldehyde→2-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-6-(methoxymethoxy)benzaldehyde→2-bromobenzene-1,3-diol→2-bromo-1,3-bis(methoxymethoxy)benzene→2,6-bis(methoxymethoxy)benzaldehyde
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | (2-Chloro-3-pyridinyl)methanol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 1-Isopropyl-1H-pyrazole-5-boronic acid, pinacol ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 2-hydroxy-6-(methoxymethoxy)benzaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 3-(chloromethyl)-2-(1-isopropyl-1H-pyrazol-5-yl)pyridine hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.