西美瑞韦钠
Tier B — Position earlySimeprevir Sodium
Targets：NS3/NS4A
Brand：Olysio/Sovriad、Olysio、Sovriad、Galexos
Indications (approved)：丙型肝炎
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| SIME-001 | 1027355-51-6 | 3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid |
| SIME-002 | 55863-02-0 | N-methylhex-5-en-1-amine |
| SIME-003 | 862174-98-9 | (1R,4R,5R)-N-(hex-5-en-1-yl)-N-methyl-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxamide |
| SIME-004 | 922727-92-2 | (1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentanecarboxylic acid |
| SIME-005 | 259214-56-7 | (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride |
| SIME-006 | 922727-93-3 | (1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate |
| SIME-007 | 923289-21-8 | 2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol |
| SIME-008 | 923604-56-2 | (1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate |
| SIME-009 | 923604-57-3 | (2R,3aR,11aS,12aR,14aR,Z)-ethyl 2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,12a,13,14,14a-hexadecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a-carboxylate |
| SIME-010 | 154350-29-5 | cyclopropanesulfonamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| SIME-002 | 55863-02-0 | N-methylhex-5-en-1-amine |
| SIME-007 | 923289-21-8 | 2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol |
| SIME-008 | 923604-56-2 | (1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate |
| SIME-011 | 1703-58-8 | tetraethyl butane-1,2,3,4-tetracarboxylate |
| SIME-012 | 4373-15-3 | 4-oxocyclopentane-1,2-dicarboxylic acid |
| SIME-013 | 1703-61-3 | 4-hydroxycyclopentane-1,2-dicarboxylic acid |
| SIME-014 | 1458173-82-4 | 4-hydroxycyclopentane-1,2-dicarboxylic acid |
| SIME-015 | 541-41-3 | ethyl carbonochloridate |
| SIME-016 | 1027355-51-6 | 3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid |
| SIME-017 | 1042695-82-8 | (1S,4R,5R)-benzyl 3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylate |
| SIME-018 | 1042695-89-5 | butane-1,2,3,4-tetracarboxylic acid |
| SIME-019 | 1042695-85-1 | (1R,2R,4R)-1-benzyl 2-methyl 4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentane-1,2-dicarboxylate |
| SIME-020 | 1042695-86-2 | (1R,2R,4S)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-2-(methoxycarbonyl)cyclopentanecarboxylic acid |
| SIME-021 | 1042695-87-3 | (1R,2R,4S)-methyl 2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxylate |
| SIME-022 | - | lithium (1R,2R,4S)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxylate |
| SIME-023 | 213316-32-6 | (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate |
| Code | CAS No. | Intermediate |
|---|---|---|
| SIME-002 | 55863-02-0 | N-methylhex-5-en-1-amine |
| SIME-003 | 862174-98-9 | (1R,4R,5R)-N-(hex-5-en-1-yl)-N-methyl-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxamide |
| SIME-007 | 923289-21-8 | 2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol |
| SIME-013 | 1703-61-3 | 4-hydroxycyclopentane-1,2-dicarboxylic acid |
| SIME-021 | 1042695-87-3 | (1R,2R,4S)-methyl 2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxylate |
| SIME-024 | 1233219-41-4 | (1R)-quinolin-4-yl((1S,4S,5R)-5-vinylquinuclidin-2-yl)methanol (1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylate |
| SIME-025 | 1042695-84-0 | (1R,2R,4R)-methyl 2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentanecarboxylate |
Frequently asked questions
What are the approved indications of Simeprevir Sodium?
Approved indications include: 丙型肝炎.
When does the Simeprevir Sodium patent expire?
No public expiry year is available for Simeprevir Sodium yet; this page updates once verified.
How many synthesis routes are recorded for Simeprevir Sodium?
3 synthesis routes are recorded; the shortest is 4 steps with 24.3 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Simeprevir Sodium intermediates?
All intermediates in Simeprevir Sodium routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Simeprevir Sodium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24