← Back to patent-cliff list
CAS 923604-56-2
(1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate
Codes：SIME-008
Application context (from source-drug indications)
丙型肝炎西美瑞韦钠慢性丙型肝炎西美瑞韦钠麻疹西美瑞韦钠结核分枝杆菌感染西美瑞韦钠
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 西美瑞韦钠Simeprevir Sodium | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid→N-methylhex-5-en-1-amine→(1R,4R,5R)-N-(hex-5-en-1-yl)-N-methyl-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxamide→(1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentanecarboxylic acid→(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride→(1R,2S)-ethyl 1-((1R,2R,4S)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-hydroxycyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate→2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol→(1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate→(2R,3aR,11aS,12aR,14aR,Z)-ethyl 2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,12a,13,14,14a-hexadecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a-carboxylate→cyclopropanesulfonamide
N-methylhex-5-en-1-amine→2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol→(1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate→tetraethyl butane-1,2,3,4-tetracarboxylate→4-oxocyclopentane-1,2-dicarboxylic acid→4-hydroxycyclopentane-1,2-dicarboxylic acid→4-hydroxycyclopentane-1,2-dicarboxylic acid→ethyl carbonochloridate→3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid→(1S,4R,5R)-benzyl 3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylate→butane-1,2,3,4-tetracarboxylic acid→(1R,2R,4R)-1-benzyl 2-methyl 4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentane-1,2-dicarboxylate→(1R,2R,4S)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-2-(methoxycarbonyl)cyclopentanecarboxylic acid→(1R,2R,4S)-methyl 2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxylate→lithium (1R,2R,4S)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxylate→(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.