Difamilast
Tier C — Watch / tradeDifamilast
Targets：PDE4
Brand：モイゼルト, Moizerto
Indications (approved)：Atopic dermatitis
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| DIFAM-001 | 177429-27-5 | ethyl 4-(benzyloxy)-3-hydroxybenzoate |
| DIFAM-002 | 93652-48-3 | 4-(benzyloxy)-3-isopropoxybenzoic acid |
| DIFAM-003 | 1574285-26-9 | 4-(benzyloxy)-3-isopropoxybenzamide |
| DIFAM-004 | 70-23-5 | ethyl 3-bromo-2-oxopropanoate |
| DIFAM-005 | 1574285-28-1 | ethyl 2-(4-(benzyloxy)-3-isopropoxyphenyl)oxazole-4-carboxylate |
| DIFAM-006 | 1574285-30-5 | ethyl 2-(4-hydroxy-3-isopropoxyphenyl)oxazole-4-carboxylate |
| DIFAM-007 | 1574285-32-7 | ethyl 2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole-4-carboxylate |
| DIFAM-008 | 1574285-36-1 | (2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanol |
| DIFAM-009 | 1574285-38-3 | 4-(bromomethyl)-2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole |
| DIFAM-010 | 1074-82-4 | potassium 1,3-dioxoisoindolin-2-ide |
| DIFAM-011 | 1574285-40-7 | 2-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)isoindoline-1,3-dione |
| DIFAM-012 | 1574285-43-0 | (2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanamine hydrochloride |
| DIFAM-013 | 134-11-2 | 2-ethoxybenzoic acid |
| Difamilast | 937782-05-3 | N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide |
Frequently asked questions
What are the approved indications of Difamilast?
Approved indications include: Atopic dermatitis.
When does the Difamilast patent expire?
No public expiry year is available for Difamilast yet; this page updates once verified.
How many synthesis routes are recorded for Difamilast?
1 synthesis routes are recorded; the shortest is 10 steps with 18.58 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Difamilast intermediates?
All intermediates in Difamilast routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Difamilast intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27