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CAS 1574285-30-5
ethyl 2-(4-hydroxy-3-isopropoxyphenyl)oxazole-4-carboxylate
Codes: DIFAM-006
Application context (from source-drug indications)
Atopic dermatitisDifamilast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Difamilast | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl 4-(benzyloxy)-3-hydroxybenzoate→4-(benzyloxy)-3-isopropoxybenzoic acid→4-(benzyloxy)-3-isopropoxybenzamide→ethyl 3-bromo-2-oxopropanoate→ethyl 2-(4-(benzyloxy)-3-isopropoxyphenyl)oxazole-4-carboxylate→ethyl 2-(4-hydroxy-3-isopropoxyphenyl)oxazole-4-carboxylate→ethyl 2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole-4-carboxylate→(2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanol→4-(bromomethyl)-2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole→potassium 1,3-dioxoisoindolin-2-ide→2-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)isoindoline-1,3-dione→(2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanamine hydrochloride→2-ethoxybenzoic acid→N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide
Intermediates available on this site
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