伐度司他
Tier C — Watch / tradeVadadustat · all drugs expiring in 2030 →
Targets：HIF-PHs
Brand：Vafseo、VAFSEO、バフセオ
Indications (approved)：慢性肾功能不全、贫血
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| VADA-001 | 85331-33-5 | 3,5-dichloropicolinonitrile |
| VADA-002 | 63503-60-6 | (3-chlorophenyl)boronic acid |
| VADA-003 | 1415226-38-8 | 3-chloro-5-(3-chlorophenyl)picolinonitrile |
| VADA-004 | 1415226-39-9 | 5-(3-chlorophenyl)-3-methoxypicolinonitrile |
| VADA-005 | 1415226-40-2 | 5-(3-chlorophenyl)-3-hydroxypicolinic acid |
| VADA-006 | 5680-79-5Available | methyl glycinate hydrochloride |
| VADA-007 | 1000024-87-2 | methyl (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycinate |
| Code | CAS No. | Intermediate |
|---|---|---|
| VADA-001 | 85331-33-5 | 3,5-dichloropicolinonitrile |
| VADA-002 | 63503-60-6 | (3-chlorophenyl)boronic acid |
| VADA-006 | 5680-79-5Available | methyl glycinate hydrochloride |
| VADA-007 | 1000024-87-2 | methyl (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycinate |
| VADA-008 | 1000025-92-2 | 3,5-bis(benzyloxy)picolinonitrile |
| VADA-009 | 1956307-64-4 | 3,5-bis(benzyloxy)picolinic acid hydrochloride |
| VADA-010 | 1000025-94-4 | methyl (3,5-bis(benzyloxy)picolinoyl)glycinate |
| VADA-011 | 1000025-95-5 | methyl (3,5-dihydroxypicolinoyl)glycinate |
| VADA-012 | 1000025-96-6 | methyl (3-hydroxy-5-(((trifluoromethyl)sulfonyl)oxy)picolinoyl)glycinate |
Frequently asked questions
What are the approved indications of Vadadustat?
Approved indications include: 慢性肾功能不全, 贫血.
When does the Vadadustat patent expire?
Based on public sources, the Vadadustat patent expires in 2030.
How many synthesis routes are recorded for Vadadustat?
2 synthesis routes are recorded; the shortest is 5 steps with 0.38 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Vadadustat intermediates?
1 intermediate CAS of Vadadustat are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Vadadustat intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24