CAS 85331-33-5

3,5-dichloropicolinonitrile

Codes：VADA-001

Application context (from source-drug indications)

慢性肾功能不全伐度司他贫血伐度司他

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
伐度司他Vadadustat	Tier C — Watch / trade	2030

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

伐度司他原研路线steps: 5total yield: 0.38 g

3,5-dichloropicolinonitrile→(3-chlorophenyl)boronic acid→3-chloro-5-(3-chlorophenyl)picolinonitrile→5-(3-chlorophenyl)-3-methoxypicolinonitrile→5-(3-chlorophenyl)-3-hydroxypicolinic acid→methyl glycinate hydrochloride→methyl (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycinate

伐度司他优化路线steps: 7total yield: 0.10 g

3,5-dichloropicolinonitrile→(3-chlorophenyl)boronic acid→methyl glycinate hydrochloride→methyl (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycinate→3,5-bis(benzyloxy)picolinonitrile→3,5-bis(benzyloxy)picolinic acid hydrochloride→methyl (3,5-bis(benzyloxy)picolinoyl)glycinate→methyl (3,5-dihydroxypicolinoyl)glycinate→methyl (3-hydroxy-5-(((trifluoromethyl)sulfonyl)oxy)picolinoyl)glycinate

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