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富马酸磷丙替诺福韦

Tier B — Position early

Tenofovir Alafenamide Fumarate

Gilead Sciences Inc
Originator
2016
First approval
-
Expiry (public)
$1.07B ▲
Peak sales
化学药
Type

TargetsRT

BrandVemlidy、韦立得

Indications (approved)乙型肝炎、慢性乙型肝炎

Regional status

US
批准上市
2016-11-10
EU
批准上市
2017-01-09
China
批准上市
2019-05-09
Japan
批准上市
2016-12-19

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 1.329 kg
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
TENO-00173-24-59H-purin-6-amine
TENO-00216606-55-6(R)-4-methyl-1,3-dioxolan-2-one
TENO-00314047-28-0(R)-1-(6-amino-9H-purin-9-yl)propan-2-ol
TENO-00431618-90-3(diethoxyphosphoryl)methyl 4-methylbenzenesulfonate
TENO-005147127-20-6(R)-(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
TENO-006379270-35-6phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
TENO-00739825-33-7isopropyl L-alaninate
TENO-008379270-37-8isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate

Frequently asked questions

What are the approved indications of Tenofovir Alafenamide Fumarate?

Approved indications include: 乙型肝炎, 慢性乙型肝炎.

When does the Tenofovir Alafenamide Fumarate patent expire?

No public expiry year is available for Tenofovir Alafenamide Fumarate yet; this page updates once verified.

How many synthesis routes are recorded for Tenofovir Alafenamide Fumarate?

1 synthesis routes are recorded; the shortest is 6 steps with 1.329 kg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Tenofovir Alafenamide Fumarate intermediates?

All intermediates in Tenofovir Alafenamide Fumarate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Tenofovir Alafenamide Fumarate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24