盐酸依特卡肽
Tier C — Watch / tradeEtelcalcetide Hydrochloride
Targets：CaSR
Brand：旁必福、Parsabiv
Indications (approved)：继发性甲状旁腺功能亢进症
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ETEL-001 | - | (R)-2-amino-N-methyl-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-002 | - | (R)-2-amino-N-methyl-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-003 | - | (R)-2-((R)-2-aminopropanamido)-N-methyl-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-004 | - | (R)-2-amino-N-((R)-1-(((R)-1-(methylamino)-1-oxo-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentan-2-yl)amino)-1-oxopropan-2-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-005 | - | (R)-2-amino-N-((6R,9R,12R)-1,17-diimino-9-methyl-6-(methylcarbamoyl)-8,11-dioxo-1,17-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-2,7,10,16-tetraazaheptadecan-12-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-006 | - | (R)-2-amino-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-007 | - | (R)-2-((R)-2-aminopropanamido)-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-008 | - | (R)-2-((R)-2-((R)-2-amino-3-(tritylthio)propanamido)propanamido)-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-009 | - | (R)-2-((R)-2-((R)-2-acetamido-3-(tritylthio)propanamido)propanamido)-N-((6R,9R,12R,15R)-1,20-diimino-9-methyl-6-(methylcarbamoyl)-8,11,14-trioxo-1,20-bis(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)-12-(3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propyl)-2,7,10,13,19-pentaazaicosan-15-yl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide |
| ETEL-010 | - | (R)-2-((R)-2-((R)-2-acetamido-3-(pyridin-2-yldisulfanyl)propanamido)propanamido)-N-((6R,9R,12R,15R)-1,20-diamino-6-carbamoyl-12-(3-guanidinopropyl)-1,20-diimino-9-methyl-8,11,14-trioxo-2,7,10,13,19-pentaazaicosan-15-yl)-5-guanidinopentanamide |
| ETEL-011 | 921-01-7 | (S)-2-amino-3-mercaptopropanoic acid |
Frequently asked questions
What are the approved indications of Etelcalcetide Hydrochloride?
Approved indications include: 继发性甲状旁腺功能亢进症.
When does the Etelcalcetide Hydrochloride patent expire?
No public expiry year is available for Etelcalcetide Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Etelcalcetide Hydrochloride?
1 synthesis routes are recorded; the shortest is 16 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Etelcalcetide Hydrochloride intermediates?
All intermediates in Etelcalcetide Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Etelcalcetide Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24