曲法罗汀
Tier C — Watch / tradeTrifarotene
Targets：RAR-γ
Brand：Aklief
Indications (approved)：寻常痤疮
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| TRIFA-001 | 6310-21-0 | 2-(tert-butyl)aniline |
| TRIFA-002 | 850012-44-1 | 4-bromo-2-(tert-butyl)aniline |
| TRIFA-003 | 850012-53-2 | 1-(4-bromo-2-(tert-butyl)phenyl)pyrrolidine |
| TRIFA-004 | 895543-00-7 | (3-(tert-butyl)-4-(pyrrolidin-1-yl)phenyl)boronic acid |
| TRIFA-005 | 895542-96-8 | ethyl 4'-(2-acetoxyethoxy)-3'-bromo-[1,1'-biphenyl]-4-carboxylate |
| TRIFA-006 | 895543-08-5 | ethyl 4'-(2-acetoxyethoxy)-3''-(tert-butyl)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylate |
| TRIFA-007 | 895542-08-2 | ethyl 3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylate |
| TRIFA-008 | 895542-84-4 | ethyl 3'-bromo-4'-hydroxy-[1,1'-biphenyl]-4-carboxylate |
| TRIFA-009 | 927-68-4 | 2-bromoethyl acetate |
| Trifarotene | 895542-09-3 | 3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylic acid |
Frequently asked questions
What are the approved indications of Trifarotene?
Approved indications include: 寻常痤疮.
When does the Trifarotene patent expire?
No public expiry year is available for Trifarotene yet; this page updates once verified.
How many synthesis routes are recorded for Trifarotene?
1 synthesis routes are recorded; the shortest is 7 steps with 242 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Trifarotene intermediates?
All intermediates in Trifarotene routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Trifarotene intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24