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CAS 895542-09-3
3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylic acid
Codes：Trifarotene
Application context (from source-drug indications)
寻常痤疮曲法罗汀板层状鳞癣曲法罗汀淋巴瘤曲法罗汀
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 曲法罗汀Trifarotene | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(tert-butyl)aniline→4-bromo-2-(tert-butyl)aniline→1-(4-bromo-2-(tert-butyl)phenyl)pyrrolidine→(3-(tert-butyl)-4-(pyrrolidin-1-yl)phenyl)boronic acid→ethyl 4'-(2-acetoxyethoxy)-3'-bromo-[1,1'-biphenyl]-4-carboxylate→ethyl 4'-(2-acetoxyethoxy)-3''-(tert-butyl)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylate→ethyl 3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylate→ethyl 3'-bromo-4'-hydroxy-[1,1'-biphenyl]-4-carboxylate→2-bromoethyl acetate→3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylic acid
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