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Fluticasone Propionate
Tier C — Watch / tradeFluticasone Propionate
GSK
Originator
1990
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：GR, PLA2G4A
Brand：Flonase, Flutide, Flixotide/Flovent, Cutivate, Flixotide, Flovent
Indications (approved)：Nasal congestion, Allergic rhinitis, 鼻息肉, Rhinitis, 扁平苔藓, Rash, 接触性皮炎, 盘状红斑狼疮
Regional status
US
Approved
1990-12-14
EU
Phase III
1999-11-01
China
Approved
2000-06-16
Japan
Approved
2001-10-02
Synthetic routes & intermediates6 routes
Originator routes × 0Optimised (non-patent) × 6Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 5 · Total yield 3.6 g (Fluticasone propionate)
FLUTI-00128416-82-2FLUTI-00280473-92-3FLUTI-00380474-45-9FLUTI-00480486-69-7FLUTI-00580474-67-5Fluticasone propionate90566-53-3API · Fluticasone Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| FLUTI-001 | 28416-82-2 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid |
| FLUTI-002 | 80473-92-3 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid |
| FLUTI-003 | 80474-45-9 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid |
| FLUTI-004 | 80486-69-7 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-(((chloromethyl)thio)carbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate |
| FLUTI-005 | 80474-67-5 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-17-(((iodomethyl)thio)carbonyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate |
| Fluticasone propionate | 90566-53-3 | - |
OptimisedRoute 2Steps 6 · Total yield 83.5 g (Fluticasone propionate)
FLUTI-00128416-82-2FLUTI-00380474-45-9FLUTI-0061744-65-6FLUTI-00765429-42-7FLUTI-00816420-13-6FLUTI-009105638-31-1FLUTI-0101351451-82-5API · Fluticasone Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| FLUTI-001 | 28416-82-2 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid |
| FLUTI-003 | 80474-45-9 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid |
| FLUTI-006 | 1744-65-6 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-acetyl-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| FLUTI-007 | 65429-42-7 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid |
| FLUTI-008 | 16420-13-6 | dimethylcarbamothioic chloride |
| FLUTI-009 | 105638-31-1 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic thioanhydride |
| FLUTI-010 | 1351451-82-5 | 2-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid |
OptimisedRoute 3Steps 5 · Total yield 0.041 g (Fluticasone propionate)
FLUTI-00380474-45-9FLUTI-0115292-43-3FLUTI-0121414857-52-5FLUTI-0131414857-53-6FLUTI-0141414857-54-7FLUTI-0151414857-56-9API · Fluticasone Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| FLUTI-003 | 80474-45-9 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid |
| FLUTI-011 | 5292-43-3 | tert-butyl 2-bromoacetate |
| FLUTI-012 | 1414857-52-5 | (6S,9R,10S,11S,13S,16R,17R)-17-(((2-(tert-butoxy)-2-oxoethyl)thio)carbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate |
| FLUTI-013 | 1414857-53-6 | (6S,9R,10S,11S,13S,16R,17R)-17-(((2-(tert-butoxy)-2-oxoethyl)thio)carbonyl)-6,9-difluoro-10,13,16-trimethyl-3-oxo-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate |
| FLUTI-014 | 1414857-54-7 | 2-(((6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid |
| FLUTI-015 | 1414857-56-9 | (6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-10,13,16-trimethyl-3-oxo-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate |
OptimisedRoute 4Steps 2 · Total yield 0.4 g (Fluticasone propionate)
FLUTI-00380474-45-9FLUTI-0101351451-82-5FLUTI-01679-08-3API · Fluticasone Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| FLUTI-003 | 80474-45-9 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid |
| FLUTI-010 | 1351451-82-5 | 2-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid |
| FLUTI-016 | 79-08-3 | 2-bromoacetic acid |
OptimisedRoute 5Steps 2 · Total yield 72.9 g (FLUT-015)
FLUTI-017—FLUTI-018—FLUTI-019—API · Fluticasone Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| FLUTI-017 | - | (6S,9R,10S,11S,13S,16R,E)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-17-(1-((trimethylsilyl)oxy)ethylidene)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| FLUTI-018 | - | (6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-17-(2-((trimethylsilyl)oxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| FLUTI-019 | - | (6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
OptimisedRoute 6Steps 6 · Total yield 254.5 mg (FLUT-027)
FLUTI-023—FLUTI-02437413-91-5FLUTI-025—FLUTI-026—FLUTI-027—FLUTI-02050-24-8FLUTI-021—FLUTI-022108-24-7API · Fluticasone Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| FLUTI-023 | - | (Z)-1-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-oxoethyl acetate |
| FLUTI-024 | 37413-91-5 | 2-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate |
| FLUTI-025 | - | 2-((8S,9R,10S,11S,13S,14S)-9-bromo-11-(formyloxy)-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate |
| FLUTI-026 | - | 2-((4aS,4bS,5aS,6aS,9aS,9bS)-4a,6a-dimethyl-2-oxo-2,4a,5a,6,6a,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate |
| FLUTI-027 | - | 2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate |
| FLUTI-020 | 50-24-8 | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| FLUTI-021 | - | (Z)-2-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-hydroxyacetaldehyde |
| FLUTI-022 | 108-24-7 | acetic anhydride |
Frequently asked questions
What are the approved indications of Fluticasone Propionate?
Approved indications include: Nasal congestion, Allergic rhinitis, 鼻息肉, Rhinitis, 扁平苔藓, Rash, 接触性皮炎, 盘状红斑狼疮.
When does the Fluticasone Propionate patent expire?
No public expiry year is available for Fluticasone Propionate yet; this page updates once verified.
How many synthesis routes are recorded for Fluticasone Propionate?
6 synthesis routes are recorded; the shortest is 2 steps with 0.4 g (Fluticasone propionate) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Fluticasone Propionate intermediates?
All intermediates in Fluticasone Propionate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Fluticasone Propionate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27