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CAS 5292-43-3
1,1-Dimethylethyl monobromoacetatetert-butyl 2-bromoacetate
Codes：(II)122568-5-a、VILD-012
Application context (from source-drug indications)
注意力缺陷障碍伴多动盐酸可乐定 (Tris Pharma)高血压盐酸可乐定 (Tris Pharma)二型糖尿病维格列汀精神分裂症维格列汀血脂障碍维格列汀胰岛素抵抗维格列汀一型糖尿病维格列汀糖尿病维格列汀
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 盐酸可乐定 (Tris Pharma)Clonidine Hydrochloride (Tris Pharma) | Tier C — Watch / trade | - |
| 维格列汀Vildagliptin | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Mercaptoimidazoline→1,1-Dimethylethyl monobromoacetate→tert-Butyl [(4,5-dihydro-1H-imidazol-2-yl)sulfanyl]acetate hydrogen bromide→Methyl 2-[(2-tert-butoxy-2-oxoethyl)sulfanyl]-4,5-dihydro-1H-imidazole-1-carboxylate→2,6-Dichloroaniline
(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→tert-butyl ((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycinate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride
(S)-pyrrolidine-2-carboxamide→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride→tert-butyl ((3s,5s,7s)-adamantan-1-yl)glycinate→((3s,5s,7s)-adamantan-1-yl)glycine→tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate
Intermediates available on this site
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