图卡替尼
Tier C — Watch / tradeTucatinib · all drugs expiring in 2030 →
Targets：HER2
Brand：Tukysa
Indications (approved)：乳腺癌、结直肠癌
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBIN-001 | 17420-30-3Available | 2-amino-5-nitrobenzonitrile |
| IRBIN-002 | 1203904-18-0Available | (E)-N'-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide |
| IRBIN-003 | 2131230-48-1Available | (E)-N'-(4-amino-2-cyanophenyl)-N,N-dimethylformimidamide |
| IRBIN-004 | 124-68-5Available | 2-amino-2-methylpropan-1-ol |
| IRBIN-005 | 1429755-57-6Available | (E)-N'-(2-cyano-4-(3-(1-hydroxy-2-methylpropan-2-yl)thioureido)phenyl)-N,N-dimethylformimidamide |
| IRBIN-006 | 937263-71-3Available | 7-(4-(l2-azaneyl)-2-methylphenoxy)-[1,2,4]triazolo[1,5-a]pyridine |
| IRBIN-007 | 1429755-58-7Available | 1-(4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea |
| IRBIN-008 | 864244-98-4Available | 4-(2-methyl-4-nitrophenoxy)pyridin-2-amine |
| IRBIN-009 | - | (E)-N,N-dimethyl-N'-(4-(2-methyl-4-nitrophenoxy)pyridin-2-yl)formimidamide |
| IRBIN-010 | 937263-44-0Available | 7-(2-methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a]pyridine |
| Irbinitinib | 937263-43-9Available | N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine |
Frequently asked questions
What are the approved indications of Tucatinib?
Approved indications include: 乳腺癌, 结直肠癌.
When does the Tucatinib patent expire?
Based on public sources, the Tucatinib patent expires in 2030.
How many synthesis routes are recorded for Tucatinib?
1 synthesis routes are recorded; the shortest is 8 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Tucatinib intermediates?
10 intermediate CAS of Tucatinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Tucatinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24