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CAS 1429755-58-7
1-(4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea
Codes：IRBIN-007
Application context (from source-drug indications)
乳腺癌图卡替尼结直肠癌图卡替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 图卡替尼Tucatinib | Tier C — Watch / trade | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-amino-5-nitrobenzonitrile→(E)-N'-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide→(E)-N'-(4-amino-2-cyanophenyl)-N,N-dimethylformimidamide→2-amino-2-methylpropan-1-ol→(E)-N'-(2-cyano-4-(3-(1-hydroxy-2-methylpropan-2-yl)thioureido)phenyl)-N,N-dimethylformimidamide→7-(4-(l2-azaneyl)-2-methylphenoxy)-[1,2,4]triazolo[1,5-a]pyridine→1-(4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea→4-(2-methyl-4-nitrophenoxy)pyridin-2-amine→(E)-N,N-dimethyl-N'-(4-(2-methyl-4-nitrophenoxy)pyridin-2-yl)formimidamide→7-(2-methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a]pyridine→N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-y Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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